TA 01

Discontinued Product

Unfortunately TA 01 (Cat. No. 5383) has been withdrawn from sale for commercial reasons.
Cat.No. 5383 - TA 01 | C20H12F3N3
Description: Induces cardiomyocyte differentiation from hESCs
Chemical Name: 4-(2-(2,6-Difluorophenyl)-4-(fluorophenyl)-1H-imidazol-5-yl)pyridine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Induces cardiomyocyte differentiation from human embryonic stem cells following mesoderm induction at 1 μM. Inhibits cardiomyocyte differentiation at 5 μM. Potently inhibits CK1ε, p38α, and CK1δ (IC50 values are 6.4, 6.7 and 6.8 nM respectively).

Licensing Information

Sold under agreement from the Agency for Science, Technology and Research (A*STAR), ETPL, and affiliates including the Bioprocessing Technology Institute.

Technical Data

M. Wt 351.32
Formula C20H12F3N3
Storage Store at +4°C
Purity ≥98% (HPLC)
PubChem ID 91691129
InChI Key TWPJJJZCYVFUOA-UHFFFAOYSA-N
Smiles FC(C=C4)=CC=C4C(N=C(C3=C(F)C=CC=C3F)N2)=C2C1=CC=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 351.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.85 mL 14.23 mL 28.46 mL
5 mM 0.57 mL 2.85 mL 5.69 mL
10 mM 0.28 mL 1.42 mL 2.85 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Laco et al (2014) Cardiomyocyte differentiation of pluripotent stem cells with SB203580 analogues correlates with Wnt pathway CK1 inhibition independent of p38 MAPK signaling. J.Mol.Cell.Cardiol 80 56 PMID: 25528965

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Citations for TA 01

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Currently there are no citations for TA 01.

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Literature in this Area

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