TA 01

Pricing Availability Delivery Time Qty
Cat.No. 5383 - TA 01 | C20H12F3N3
Description: Induces cardiomyocyte differentiation from hESCs
Chemical Name: 4-(2-(2,6-Difluorophenyl)-4-(fluorophenyl)-1H-imidazol-5-yl)pyridine
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Induces cardiomyocyte differentiation from human embryonic stem cells following mesoderm induction at 1 μM. Inhibits cardiomyocyte differentiation at 5 μM. Potently inhibits CK1ε, p38α, and CK1δ (IC50 values are 6.4, 6.7 and 6.8 nM respectively).

Licensing Information

Sold under agreement from the Agency for Science, Technology and Research (A*STAR), ETPL, and affiliates including the Bioprocessing Technology Institute.

Technical Data

M. Wt 351.32
Formula C20H12F3N3
Storage Store at +4°C
Purity ≥98% (HPLC)
PubChem ID 91691129
InChI Key TWPJJJZCYVFUOA-UHFFFAOYSA-N
Smiles FC(C=C4)=CC=C4C(N=C(C3=C(F)C=CC=C3F)N2)=C2C1=CC=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.13 100
ethanol 3.51 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 351.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.85 mL 14.23 mL 28.46 mL
5 mM 0.57 mL 2.85 mL 5.69 mL
10 mM 0.28 mL 1.42 mL 2.85 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Laco et al (2014) Cardiomyocyte differentiation of pluripotent stem cells with SB203580 analogues correlates with Wnt pathway CK1 inhibition independent of p38 MAPK signaling. J.Mol.Cell.Cardiol 80 56 PMID: 25528965


If you know of a relevant reference for TA 01, please let us know.

Keywords: TA01 induces cardiomyocyte differentiation human pluripotent stem cells hpsc inhibits inhibitors ck1eta ck1e ck1δ ck1delta ck1d ck1ε p38alpha p38a p38α mapk casein kinase ESCs and iPSC

Citations for TA 01

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Stem Cells

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Pathways for TA 01

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