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Fluorescent Ion Indicators

Ion indicators are small molecules that are used to detect changes in ionic gradients in cells. The detection of metal ions often involves chelation, where the indicator forms a complex with the target metal ion, leading to a chemical or physical change in the indicator that can be analysed with spectroscopic or electrochemical techniques.

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Cat. No. Product Name / Activity
7444 DA ZP1
Fluorogenic Zn(II) sensor for isolation of stem cell derived β cells
6255 Fluo-4 AM
Cell-permeable, fluorescent Ca2+ indicator
2220 FURA-2AM
Fluorescent Ca2+ indicator
6704 Indo 1AM
Fluorescent Ca2+ indicator
7870 ING-2 AM
Fluorescent sodium ion (Na+) indicator, membrane permeable
7871 IPG-4 AM
Fluorescent potassium ion (K+) indicator, membrane permeable
7855 Mag-Fura-2 AM
Magnesium (Mg2+) indicator, membrane permeable
7856 MQAE
Fluorescent Cl- indicator; membrane permeable
6256 OG 488 BAPTA-1 AM
Cell-permeable, fluorescent Ca2+ indicator
7873 Phen Green SK diacetate
Heavy metal ion indicator, membrane permeable

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Alterations in a fluorescent ion indicator's fluorescence intensity or emission wavelength, caused by changes in ion concentration, allow temporal and physical changes to be visualized. These changes can be measured in real time using flow cytometry or fluorescence microscopy and can be used in various research fields including neuroscience, cardiology, and metabolism.

Fluorescent ion indicators provide valuable insights into the effects of drug compounds on cell ion gradients and are compatible with high throughput screening assays. They can be used to identify novel compounds that modulate ion channel activity, understand drug mechanisms of action, and monitor ion dynamics with high sensitivity and selectivity.

Literature for Fluorescent Ion Indicators

Tocris offers the following scientific literature for Fluorescent Ion Indicators to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Fluorescent Dyes and Probes Research Product Guide

Fluorescent Dyes and Probes Research Product Guide

This product guide provides a background to the use of Fluorescent Dyes and Probes, as well as a comprehensive list of our:

  • Fluorescent Dyes, including dyes for flow cytometry
  • Fluorescent Probes and Stains, including our new MitoBrilliantTM mitochondria stains
  • Tissue Clearing Kits and Reagents
  • Aptamer-based RNA Imaging Reagents
  • Fluorescent Probes for Imaging Bacteria
  • TSA VividTM Fluorophore Kits
  • TSA Reagents for Enhancing IHC, ICC & FISH Signals