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DA ZP1 New
Biological Activity for DA ZP1
DA ZP1 (diacetylated Zinpyr1) is a fluorogenic Zn(II) sensor (Kd Zn2+ = 0.6 nM). It can be used to image and isolate pancreatic β-cells and β-like cells in vitro. Used to purify live stem cell-derived β-like cells. It can image transplanted islet grafts and endogenous mouse islets in vivo. DA ZP1 is non-fluorescent in the absence of Zn(II) ions but its binding with Zn(II) promotes hydrolytic cleavage of the acetyl groups, generating a strong fluorescent signal. Excitation and emission maxima (λ) are 490 nm and 522 nm, respectively.
Optical Data for DA ZP1
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Technical Data for DA ZP1
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for DA ZP1
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for DA ZP1
The following data is based on the product molecular weight 907.81. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.02 mM||55.08 mL||275.39 mL||550.78 mL|
|0.1 mM||11.02 mL||55.08 mL||110.16 mL|
|0.2 mM||5.51 mL||27.54 mL||55.08 mL|
|1 mM||1.1 mL||5.51 mL||11.02 mL|
References for DA ZP1
References are publications that support the biological activity of the product.
Kahraman et al (2021) Harnessing reaction-based probes to preferentially target pancreatic β-cells and β-like cells. Life Sci.Alliance 4 e202000840 PMID: 33514654
Zastrow et al (2016) Reaction-based probes for imaging mobile zinc in live cells and tissues. ACS Sens. 32 32 PMID: 26878065
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Fluorescent Dyes and Probes Research Product Guide
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