Pricing Availability   Qty
Description: Fluorescent sodium ion (Na+) indicator, membrane permeable
Chemical Name: Bis(acetoxymethyl) 3,3'-(6-(acetoxymethoxy)-4,5-dichloro-9-(3-methoxy-4-(13-(2-methoxy-4-methylphenyl)-1,4,10-trioxa-7,13-diazacyclopentadecan-7-yl)phenyl)-3-oxo-3H-xanthene-2,7-diyl)dipropionate
Purity: ≥90% (HPLC)
Literature (1)

Biological Activity for ING-2 AM

ING-2 AM is a membrane-permeable fluorescent sodium ion (Na+) indicator. It binds to sodium (Kd = 20 mM). Excitation and emission maxima (λ) are 525 and 545 nm, respectively. It displays 20-fold selectivity over K+ ions. It is used in in vitro and in situ to detect real-time sodium influx.

It is recommended to prepare stock solutions in DMSO.

Optical Data for ING-2 AM

λabs 525 nm
λem 545 nm
Cell Permeable Yes
Application Confocal microscopy, Flow cytometry, Two-photon microscopy

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Technical Data for ING-2 AM

M. Wt 1083.96
Formula C53H60Cl2N2O18
Storage Store at -20°C
Purity ≥90% (HPLC)
CAS Number 1642554-49-1
PubChem ID 163341954

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for ING-2 AM

References are publications that support the biological activity of the product.

Gregoriades et al (2019) Genetic and pharmacological inactivation of apical Na+-K+-2Cl- cotransporter 1 in choroid plexus epithelial cells reveals the physiological function of the cotransporter. Am.J.Physiol.Cell Physiol. 316 C525 PMID: 30576237

Blömer et al (2021) Ultrafast sodium imaging of the axon initial segment of neurons in mouse brain slices. Curr.Protoc. 1 e64 PMID: 33657273

Naumann et al (2018) Photophysical properties of Na+ -indicator dyes suitable for quantitative two-photon fluorescence-lifetime measurements. J.Microsc. 272 136 PMID: 30191999

Roder et al (2014) ANG-2 for quantitative Na(+) determination in living cells by time-resolved fluorescence microscopy. Photochem.Photobiol.Sci. 13 1699 PMID: 25311309

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Keywords: ING-2 AM, ING-2 AM supplier, ING-2AM, membrane, permeant, permeable, fluorescent, probe, fluorescein, detection, fluorescence, indicators, sensors, sodium, ions, Na, ion, intracellular, Fluorescent, Ion, Indicators, 7870, Tocris Bioscience

Citations for ING-2 AM

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Fluorescent Dyes and Probes Research Product Guide

Fluorescent Dyes and Probes Research Product Guide

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