OG 488 BAPTA-1 AM

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Cat.No. 6256 - OG 488 BAPTA-1 AM | C59H53F2N3O26 | CAS No. 244167-57-5
Description: Cell-permeable, fluorescent Ca2+ indicator
Chemical Name: N-[2-[(Acetyloxy)methoxy]-2-oxoethyl]-N-[4-[[[3',6'-bis(acetyloxy)-2',7'-difluoro-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl]carbonyl]amino]-2-[2-[2-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]phenoxy]ethoxy]phenyl]glycine (acetyloxy)methyl ester
Purity: ≥90% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Cell-permeable, fluorescently labeled Ca2+ indicator. Composed of a green fluorescent probe (OG 488, Cat. No. 6257) conjugated to a cell-permeable Ca2+ chelator (BAPTA AM, Cat. No. 2787). Fluorescent intensity increases upon Ca2+ binding. Displays uniform cellular distribution with minimal subcellular compartmentalization.

Technical Data

M. Wt 1258.06
Formula C59H53F2N3O26
Storage Store at -20°C
Purity ≥90% (HPLC)
CAS Number 244167-57-5
PubChem ID 102028682
InChI Key NQVWLDWXFNDFLA-UHFFFAOYSA-N
Smiles FC1=CC2=C(C3=CC=C(C(NC4=CC=C(N(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O)C(OCCOC5=CC=CC=C5N(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O)=C4)=O)C=C3C([O-])=O)C6=CC(F)=C(OC(C)=O)C=C6[O+]=C2C=C1OC(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 1.26 1

Preparing Stock Solutions

The following data is based on the product molecular weight 1258.06. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.01 mM 79.49 mL 397.44 mL 794.87 mL
0.05 mM 15.9 mL 79.49 mL 158.97 mL
0.1 mM 7.95 mL 39.74 mL 79.49 mL
0.5 mM 1.59 mL 7.95 mL 15.9 mL

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References

References are publications that support the biological activity of the product.

Thomas et al (2000) A comparison of fluorescent Ca2+ indicator properties and their use in measuring elementary and global Ca2+ signals Cell Calcium 28 213 PMID: 11032777


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Keywords: OG 488 BAPTA-1 AM, OG 488 BAPTA-1 AM supplier, OG488, BAPTA-1AM, fluorescent, calcium, indicator, chelator, cell, permeable, Ion, Indicators, General, Calcium, Signaling, Agents, 6256, Tocris Bioscience

Citations for OG 488 BAPTA-1 AM

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