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Description: Fluorescent Cl- indicator; membrane permeable
Chemical Name: 1-(2-Ethoxy-2-oxoethyl)-6-methoxyquinolin-1-ium bromide
Purity: ≥95% (HPLC)
Literature (1)

Biological Activity for MQAE

MQAE is a membrane-permeable intracellular chloride ion (Cl-) indicator. The fluorescence intensity of MQAE decreases proportionally as Cl- ions increase. Excitation/emission maxima (λ) are 355 nm and 460 nm respectively. Can be used in fluorescence microscopy and flow cytometry, suitable for use in vivo and in vitro.

Optical Data for MQAE

MQAE Dye Spectra
λabs 355 nm
λem 460 nm
Extinction Coefficient (ε) 4850 M-1cm-1
Cell Permeable Yes
pH Sensitivity Insensitive
Application Confocal imaging, Flow cytometry

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Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.

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Technical Data for MQAE

M. Wt 326.19
Formula C14H16BrNO3
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 162558-52-3
PubChem ID 2762651
Smiles O=C(C[N+]1=CC=CC2=CC(OC)=CC=C21)OCC.[Br-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MQAE

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 3.26 10
water 3.26 10

Preparing Stock Solutions for MQAE

The following data is based on the product molecular weight 326.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 30.66 mL 153.28 mL 306.57 mL
0.5 mM 6.13 mL 30.66 mL 61.31 mL
1 mM 3.07 mL 15.33 mL 30.66 mL
5 mM 0.61 mL 3.07 mL 6.13 mL

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References for MQAE

References are publications that support the biological activity of the product.

Verkman et al (1989) Synthesis and characterization of improved chloride-sensitive fluorescent indicators for biological applications. Anal.Biochem. 178 355 PMID: 2751097

Wan et al (2019) An ATP-regulated ion transport nanosystem for homeostatic perturbation therapy and sensitizing photodynamic therapy by autophagy inhibition of tumors. ACS Cent.Sci. 5 327 PMID: 30834321

If you know of a relevant reference for MQAE, please let us know.

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Citations for MQAE

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Fluorescent Dyes and Probes Research Product Guide

Fluorescent Dyes and Probes Research Product Guide

This product guide provides a background to the use of Fluorescent Dyes and Probes, as well as a comprehensive list of our:

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