Fluorescent Ca2+ indicator. Selective for Ca2+ over other divalent cations Mg2+, Zn2+, Fe2+ and Mn2+. Used to determine intracellular Ca2+ concentration.
F 127 (Cat. No. 6253) for the solubilization of FURA-2AM is also available.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 1001.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||9.98 mL||49.91 mL||99.82 mL|
|0.5 mM||2 mL||9.98 mL||19.96 mL|
|1 mM||1 mL||4.99 mL||9.98 mL|
|5 mM||0.2 mL||1 mL||2 mL|
References are publications that support the biological activity of the product.
Grynkiewicz et al (1985) A new generation of Ca2+ indicators with greatly improved fluorescence properties. J.Biol.Chem. 260 3440 PMID: 3838314
Wang et al (2008) Sildenafil inhibits human pulmonary artery smooth muscle cell proliferation by decreasing capacitative Ca2+ entry. J.Pharmacol.Sci. 108 71 PMID: 18818482
If you know of a relevant reference for FURA-2AM, please let us know.
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Keywords: FURA-2AM, FURA-2AM supplier, Fluorescent, Ca2+, indicator, Probes, Calcium, Signaling, Signalling, Agents, General, 2220, Tocris Bioscience
2 Citations for FURA-2AM
Citations are publications that use Tocris products. Selected citations for FURA-2AM include:
Luo et al (2015) Ketamine attenuates the Na+-dependent Ca2+ overload in rabbit ventricular myocytes in vitro by inhibiting late Na+ and L-type Ca2+ currents. Mol Neurodegener 36 1327 PMID: 26456586
Bayliss and Evans (2013) Characterisation of AmphiAmR11, an amphioxus (Branchiostoma floridae) D2-dopamine-like G protein-coupled receptor. PLoS One 8 e80833 PMID: 24265838
Do you know of a great paper that uses FURA-2AM from Tocris? Please let us know.
Reviews for FURA-2AM
Average Rating: 5 (Based on 1 Review.)
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Used in live cell calcium imaging assay to study glutamate receptor signaling in neurons. Used at a concentration of 5 micromolar (along with pluronic). Images shows changes in fura-2 fluorescence pre (left) and post(right) glutamate stimulation.
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