TBK1 control PROTAC® 4

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Description: Negative control for TBK1 PROTAC® 3i (Cat. No. 7259)
Chemical Name: (2S,4S)-1-((S)-18-(4-((5-Bromo-4-((3-(N-methylcyclobutanecarboxamido)propyl)amino)pyrimidin-2-yl)amino)phenoxy)-2-(tert-butyl)-4-oxo-6,10,15-trioxa-3-azaoctadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for TBK1 control PROTAC® 4

TBK1 control PROTAC® 4 is a negative control for TBK1 PROTAC® 3i (Cat. No. 7259). Binds TBK1 with high affinity, but exhibits no significant degradation of TBK1.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data for TBK1 control PROTAC® 4

M. Wt 1093.19
Formula C53H74BrN9O9S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2052306-31-5
PubChem ID 145969727

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TBK1 control PROTAC® 4

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 109.32 100

Preparing Stock Solutions for TBK1 control PROTAC® 4

The following data is based on the product molecular weight 1093.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.91 mL 4.57 mL 9.15 mL
5 mM 0.18 mL 0.91 mL 1.83 mL
10 mM 0.09 mL 0.46 mL 0.91 mL
50 mM 0.02 mL 0.09 mL 0.18 mL

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Product Datasheets for TBK1 control PROTAC® 4

References for TBK1 control PROTAC® 4

References are publications that support the biological activity of the product.

Crew et al (2018) Identification and characterization of Von Hippel-Lindau-recruiting proteolysis targeting chimeras (PROTACs) of TANK-binding kinase 1. J.Med.Chem. 61 583 PMID: 28692295

If you know of a relevant reference for TBK1 control PROTAC® 4, please let us know.

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Citations for TBK1 control PROTAC® 4

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Targeted Protein Degradation Research Product Guide

Targeted Protein Degradation Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Ubiquitin-Proteasome System Proteins
  • Assays for Protein Degradation
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia