Pricing Availability   Qty
Description: Potent Smoothened receptor antagonist
Chemical Name: rel-N-[6-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-3-pyridinyl]-2-methyl-4'-(trifluoromethoxy)[1,1'-biphenyl]-3-carboxamide
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for Sonidegib

Sonidegib is a potent Smoothened (Smo) receptor antagonist (IC50 values are 1.3 nM and 2.5 nM at mouse and human receptors, respectively). Inhibits growth of a variety of tumor types including basal cell carcinoma, small cell lung cancer and medulloblastoma. Sonidegib inhibits Hh pathway in CD34+ chronic myeloid leukemia cells; it reduces both the number of cells and self-renewal ability. Brain penetrant and orally bioavailable.

Technical Data for Sonidegib

M. Wt 485.51
Formula C26H26F3N3O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 956697-53-3
Smiles CC1=C(C2=CC=C(C=C2)OC(F)(F)F)C=CC=C1C(NC3=CN=C(N4C[C@H](O[C@H](C4)C)C)C=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Sonidegib

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 48.55 100

Preparing Stock Solutions for Sonidegib

The following data is based on the product molecular weight 485.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.06 mL 10.3 mL 20.6 mL
5 mM 0.41 mL 2.06 mL 4.12 mL
10 mM 0.21 mL 1.03 mL 2.06 mL
50 mM 0.04 mL 0.21 mL 0.41 mL

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References for Sonidegib

References are publications that support the biological activity of the product.

Pan et al (2010) Discovery of NVP-LDE225, a potent and selective smoothened antagonist. ACS Med.Chem.Lett. 1 130 PMID: 24900187

Irvine et al (2016) Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia. Sci.Rep. 6 25476 PMID: 27157927

If you know of a relevant reference for Sonidegib, please let us know.

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Keywords: Sonidegib, Sonidegib supplier, smoothened, smo, antagonist, tumor, growth, inhibitors, lung, medulloblastoma, SCLC, BCC, basal, cell, carcinoma, Hh, hedgehog, Smoothened, Receptors, 7826, Tocris Bioscience

Citations for Sonidegib

Citations are publications that use Tocris products.

Currently there are no citations for Sonidegib. Do you know of a great paper that uses Sonidegib from Tocris? Please let us know.

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Literature in this Area

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Stem Cell Research Product Guide

Stem Cell Research Product Guide

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