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Biological Activity for AP C5
AP C5 is a potent and selective protein kinase G type II (PKG2) inhibitor (pIC50 = 7.2). Displays >20-fold selectivity for PKG2 over PKG1 and PKA (pIC50 values are 4.6 and 4.8 for PKG1 and PKA, respectively). Blocks 8-pCPT-cGMP-dependent VASP phosphorylation in intestinal organoids. Also attenuates toxin-stimulated anion secretory responses in mouse intestinal tissue.
Compound Libraries for AP C5
Technical Data for AP C5
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AP C5
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for AP C5
The following data is based on the product molecular weight 275.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.63 mL||18.16 mL||36.32 mL|
|5 mM||0.73 mL||3.63 mL||7.26 mL|
|10 mM||0.36 mL||1.82 mL||3.63 mL|
|50 mM||0.07 mL||0.36 mL||0.73 mL|
References for AP C5
References are publications that support the biological activity of the product.
Bijvelds et al (2018) Selective inhibition of intestinal guanosine 3',5'-cyclic monophosphate signaling by small-molecule protein kinase inhibitors. J.Biol.Chem. 293 8173 PMID: 29653944
If you know of a relevant reference for AP C5, please let us know.
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Keywords: AP C5, AP C5 supplier, APC5, protein, kinase, g, type, 2, II, inhibitors, inhibits, guanosine, 3,5-cyclic, monophosphate, dependent, Protein, Kinase, G, 6626, Tocris Bioscience
Citations for AP C5
Citations are publications that use Tocris products.
Currently there are no citations for AP C5. Do you know of a great paper that uses AP C5 from Tocris? Please let us know.
Reviews for AP C5
Average Rating: 5 (Based on 1 Review.)
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We developed a model system to form purified alternative pathway (AP) C5 convertases on C3b-coated beads and quantify C5 conversion via functional analysis of released C5a.
Literature in this Area
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