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Description: Potent and selective PKG2 inhibitor
Chemical Name: 4-[4-(1H-Imidazol-1-yl)phenyl]-N-2-propyn-1-yl-2-pyrimidinamine
Purity: ≥98% (HPLC)
Reviews (1)
Literature (1)

Biological Activity for AP C5

AP C5 is a potent and selective protein kinase G type II (PKG2) inhibitor (pIC50 = 7.2). Displays >20-fold selectivity for PKG2 over PKG1 and PKA (pIC50 values are 4.6 and 4.8 for PKG1 and PKA, respectively). Blocks 8-pCPT-cGMP-dependent VASP phosphorylation in intestinal organoids. Also attenuates toxin-stimulated anion secretory responses in mouse intestinal tissue.

Compound Libraries for AP C5

AP C5 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for AP C5

M. Wt 275.31
Formula C16H13N5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2234272-10-5
PubChem ID 137919866
Smiles C#CCNC1=NC(C2=CC=C(N3C=CN=C3)C=C2)=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AP C5

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 27.53 100
1eq. HCl 27.53 100

Preparing Stock Solutions for AP C5

The following data is based on the product molecular weight 275.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.63 mL 18.16 mL 36.32 mL
5 mM 0.73 mL 3.63 mL 7.26 mL
10 mM 0.36 mL 1.82 mL 3.63 mL
50 mM 0.07 mL 0.36 mL 0.73 mL

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References for AP C5

References are publications that support the biological activity of the product.

Bijvelds et al (2018) Selective inhibition of intestinal guanosine 3',5'-cyclic monophosphate signaling by small-molecule protein kinase inhibitors. J.Biol.Chem. 293 8173 PMID: 29653944

If you know of a relevant reference for AP C5, please let us know.

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Keywords: AP C5, AP C5 supplier, APC5, protein, kinase, g, type, 2, II, inhibitors, inhibits, guanosine, 3,5-cyclic, monophosphate, dependent, Protein, Kinase, G, 6626, Tocris Bioscience

Citations for AP C5

Citations are publications that use Tocris products.

Currently there are no citations for AP C5. Do you know of a great paper that uses AP C5 from Tocris? Please let us know.

Reviews for AP C5

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Development of a model system to form purified alternative pathway (AP) C5 convertases.
By Anonymous on 12/24/2019
Species: Human

We developed a model system to form purified alternative pathway (AP) C5 convertases on C3b-coated beads and quantify C5 conversion via functional analysis of released C5a.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.