AP C5

Pricing Availability   Qty
Cat.No. 6626 - AP C5 | C16H13N5 | CAS No. 2234272-10-5
Description: Potent and selective PKG2 inhibitor
Chemical Name: 4-[4-(1H-Imidazol-1-yl)phenyl]-N-2-propyn-1-yl-2-pyrimidinamine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity

Potent and selective protein kinase G type II (PKG2) inhibitor (pIC50 = 7.2). Displays >20-fold selectivity for PKG2 over PKG1 and PKA (pIC50 values are 4.6 and 4.8 for PKG1 and PKA, respectively). Blocks 8-pCPT-cGMP-dependent VASP phosphorylation in intestinal organoids. Also attenuates toxin-stimulated anion secretory responses in mouse intestinal tissue.

Technical Data

M. Wt 275.31
Formula C16H13N5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2234272-10-5
PubChem ID 137919866
InChI Key QKHQFSQJQKGFAA-UHFFFAOYSA-N
Smiles C#CCNC1=NC(C2=CC=C(N3C=CN=C3)C=C2)=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.53 100
1eq. HCl 27.53 100

Preparing Stock Solutions

The following data is based on the product molecular weight 275.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.63 mL 18.16 mL 36.32 mL
5 mM 0.73 mL 3.63 mL 7.26 mL
10 mM 0.36 mL 1.82 mL 3.63 mL
50 mM 0.07 mL 0.36 mL 0.73 mL

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References

References are publications that support the biological activity of the product.

Bijvelds et al (2018) Selective inhibition of intestinal guanosine 3',5'-cyclic monophosphate signaling by small-molecule protein kinase inhibitors. J.Biol.Chem. 293 8173 PMID: 29653944


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Keywords: AP C5, AP C5 supplier, APC5, protein, kinase, g, type, 2, II, inhibitors, inhibits, guanosine, 3,5-cyclic, monophosphate, dependent, Protein, Kinase, G, 6626, Tocris Bioscience

Citations for AP C5

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