Rp-8-Br-PET-cGMPS
Biological Activity
Competitive, reversible cGMP-dependent protein kinase (PKG) inhibitor; cGMP analog.
This product is sold in units of 560μg, equivalent to 1μmol.
Technical Data
| M. Wt | 562.27 |
| Formula | C18H14BrN5NaO6PS |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 185246-32-6 |
| PubChem ID | 23695925 |
| InChI Key | PNUXBFRWMZKKAJ-IPZAVTHYSA-M |
| Smiles | [H][C@@]([C@@](O[C@@H](N3C(Br)=NC5=C3NC4=NC(C6=CC=CC=C6)=CN4C5=O)[C@@H]2O)([H])CO1)2O[P@@]1(S[Na])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 11.25 | 20 | |
| DMSO | 22.49 | 40 |
Preparing Stock Solutions
The following data is based on the product molecular weight 562.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.4 mM | 4.45 mL | 22.23 mL | 44.46 mL |
| 2 mM | 0.89 mL | 4.45 mL | 8.89 mL |
| 4 mM | 0.44 mL | 2.22 mL | 4.45 mL |
| 20 mM | 0.09 mL | 0.44 mL | 0.89 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the biological activity of the product.
Wei et al (1996) Identification of competitive antagonists of the rod photoreceptor cGMP-gated cation channel: beta-phenyl-1,N2-etheno-substituted cGMP analogues as probes of the cGMP-binding site. Biochemistry 35 16815 PMID: 8988020
Qi et al (2007) Protein kinase G regulates the basal tension and plays a major role in nitrovasodilator-induced relaxation of porcine coronary veins. Br.J.Pharmacol. 152 1060 PMID: 17891157
Valtcheva et al (2008) The commonly used cGMP-dependent protein kinase type I (cGKI) inhibitor Rp-8-Br-PET-cGMPS can activate cGKI in vitro and in intact cells. J.Biol.Chem. 284 556 PMID: 19008225
If you know of a relevant reference for Rp-8-Br-PET-cGMPS, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Rp-8-Br-PET-cGMPS, Rp-8-Br-PET-cGMPS supplier, Protein, kinase, G, inhibitors, inhibits, PKG, Kinases, cGMP-dependent, Kinase, 3028, Tocris Bioscience
2 Citations for Rp-8-Br-PET-cGMPS
Citations are publications that use Tocris products. Selected citations for Rp-8-Br-PET-cGMPS include:
Lin et al (2008) Integrin regulation of cytoplasmic calcium in excitatory neurons depends upon glutamate receptors and release from intracellular stores. Cell 37 770 PMID: 18289871
Berlinguer-Palmini et al (2013) GPR35 activation reduces Ca2+ transients and contributes to the kynurenic acid-dependent reduction of synaptic activity at CA3-CA1 synapses. PLoS One 8 e82180 PMID: 24312407
Do you know of a great paper that uses Rp-8-Br-PET-cGMPS from Tocris? Please let us know.
Reviews for Rp-8-Br-PET-cGMPS
Average Rating: 5 (Based on 1 Review.)
Have you used Rp-8-Br-PET-cGMPS?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
Used in cultured neurons at 10 uM
Excellent PKG inhibitor
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
Kinases Product Listing
A collection of over 400 products for kinase research, the listing includes inhibitors of:
- Receptor Tyrosine Kinases
- Protein Kinases A, C, D and G
- PI-3 Kinase, Akt and mTOR
- MAPK Signaling
- Receptor Serine/Threonine Kinases
Pain Research Product Guide
A collection of over 250 products for pain research, the guide includes research tools for the study of:
- Nociception
- Ion Channels
- G-Protein-Coupled Receptors
- Intracellular Signaling
Angiogenesis in Cancer Poster
Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.
