Rp-8-Br-PET-cGMPS

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Cat.No. 3028 - Rp-8-Br-PET-cGMPS | C18H14BrN5NaO6PS | CAS No. 185246-32-6
Description: Protein kinase G inhibitor
Chemical Name: 2-Bromo-3,4-dihydro-3-[3,5-O-[(R)-mercaptophosphinylidene]-β-D-ribofuranosyl]-6-phenyl-9H-Imidazo[1,2-a]purin-9-one sodium salt
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews (1)
Literature

Biological Activity

Competitive, reversible cGMP-dependent protein kinase (PKG) inhibitor; cGMP analog.

This product is sold in units of 560μg, equivalent to 1μmol.

Technical Data

M. Wt 562.27
Formula C18H14BrN5NaO6PS
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 185246-32-6
PubChem ID 23695925
InChI Key PNUXBFRWMZKKAJ-IPZAVTHYSA-M
Smiles [H][C@@]([C@@](O[C@@H](N3C(Br)=NC5=C3NC4=NC(C6=CC=CC=C6)=CN4C5=O)[C@@H]2O)([H])CO1)2O[P@@]1(S[Na])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 11.25 20
DMSO 22.49 40

Preparing Stock Solutions

The following data is based on the product molecular weight 562.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.4 mM 4.45 mL 22.23 mL 44.46 mL
2 mM 0.89 mL 4.45 mL 8.89 mL
4 mM 0.44 mL 2.22 mL 4.45 mL
20 mM 0.09 mL 0.44 mL 0.89 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Wei et al (1996) Identification of competitive antagonists of the rod photoreceptor cGMP-gated cation channel: beta-phenyl-1,N2-etheno-substituted cGMP analogues as probes of the cGMP-binding site. Biochemistry 35 16815 PMID: 8988020

Qi et al (2007) Protein kinase G regulates the basal tension and plays a major role in nitrovasodilator-induced relaxation of porcine coronary veins. Br.J.Pharmacol. 152 1060 PMID: 17891157

Valtcheva et al (2008) The commonly used cGMP-dependent protein kinase type I (cGKI) inhibitor Rp-8-Br-PET-cGMPS can activate cGKI in vitro and in intact cells. J.Biol.Chem. 284 556 PMID: 19008225


If you know of a relevant reference for Rp-8-Br-PET-cGMPS, please let us know.

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Keywords: Rp-8-Br-PET-cGMPS, Rp-8-Br-PET-cGMPS supplier, Protein, kinase, G, inhibitors, inhibits, PKG, Kinases, cGMP-dependent, Kinase, 3028, Tocris Bioscience

2 Citations for Rp-8-Br-PET-cGMPS

Citations are publications that use Tocris products. Selected citations for Rp-8-Br-PET-cGMPS include:

Lin et al (2008) Integrin regulation of cytoplasmic calcium in excitatory neurons depends upon glutamate receptors and release from intracellular stores. Cell 37 770 PMID: 18289871

Berlinguer-Palmini et al (2013) GPR35 activation reduces Ca2+ transients and contributes to the kynurenic acid-dependent reduction of synaptic activity at CA3-CA1 synapses. PLoS One 8 e82180 PMID: 24312407


Do you know of a great paper that uses Rp-8-Br-PET-cGMPS from Tocris? Please let us know.

Reviews for Rp-8-Br-PET-cGMPS

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PKG inhibitor in vitro
By Anonymous on 08/11/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Neuron

Used in cultured neurons at 10 uM

Excellent PKG inhibitor


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