KT 5823

Pricing Availability   Qty
Description: Selective protein kinase G inhibitor
Chemical Name: (9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-methoxy-2,9-dimethyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester
Purity: ≥95% (HPLC)
Datasheet
Citations (6)
Reviews
Literature (1)

Biological Activity for KT 5823

KT 5823 is a selective inhibitor of protein kinase G (Ki values are 0.23, 4 and > 10 μM for inhibition of PKG, PKC and PKA respectively). Inhibits SNP-stimulated PKG activity with an IC50 of 60 nM in dispersed smooth muscle cells and has little effect on PKA activity at concentrations of up to 10 μM.

Technical Data for KT 5823

M. Wt 495.53
Formula C29H25N3O5
Storage Desiccate at -20°C
Purity ≥95% (HPLC)
CAS Number 126643-37-6
PubChem ID 108152
InChI Key QTYMDECKVKSGSM-YMUMJAELSA-N
Smiles [H][C@]18O[C@](N6C4=C3N1C2=CC=CC=C2C3=C7C(CN(C7=O)C)=C4C5=CC=CC=C56)([C@]([C@@](OC)=O)(OC)C8)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for KT 5823

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 24.78 50

Preparing Stock Solutions for KT 5823

The following data is based on the product molecular weight 495.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.04 mL 20.18 mL 40.36 mL
2.5 mM 0.81 mL 4.04 mL 8.07 mL
5 mM 0.4 mL 2.02 mL 4.04 mL
25 mM 0.08 mL 0.4 mL 0.81 mL

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Product Datasheets for KT 5823

Certificate of Analysis / Product Datasheet
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References for KT 5823

References are publications that support the biological activity of the product.

Gadbois et al (1992) Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells. Proc.Natl.Acad.Sci.U.S.A. 89 8626 PMID: 1528872

Murthy and Makhlouf (1995) Interaction of cA-kinase and cG-kinase in mediating relaxation of dispersed smooth muscle cells. Am.J.Physiol. 268 C171 PMID: 7840145

Smolenski et al (1998) Functional analysis of cGMP-dependent protein kinases I and II as mediators of NO/cGMP effects. Naunyn Schmiedebergs Arch.Pharmacol. 358 134 PMID: 9721015


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Keywords: KT 5823, KT 5823 supplier, Selective, protein, kinases, G, inhibitors, inhibits, PKG, cGMP, KT5823, Protein, Kinase, 1289, Tocris Bioscience

6 Citations for KT 5823

Citations are publications that use Tocris products. Selected citations for KT 5823 include:

Kuo et al (2014) A xanthine-derivative K(+)-channel opener protects against serotonin-induced cardiomyocyte hypertrophy via the modulation of protein kinases. Int J Biol Sci 10 64 PMID: 24391452

Jayabal et al (2023) Nitric oxide suppression by secreted frizzled-related protein 2 drives retinoblastoma Cell Rep 42 112103 PMID: 36773293

Livingstone et al (2019) Secreted Amyloid Precursor Protein-Alpha Promotes Arc Protein Synthesis in Hippocampal Neurons. Front Mol Neurosci 12 198 PMID: 31474829

Pulkkinen et al (2012) The bitter taste receptor (TAS2R) agonists denatonium and chloroquine display distinct patterns of relaxation of the guinea pig trachea. Am J Physiol Lung Cell Mol Physiol 303 L956 PMID: 22962016


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Literature in this Area

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