8-Bromo-cGMP, sodium salt

Pricing Availability   Qty
Description: cGMP analog; activates PKG
Chemical Name: 8-Bromoguanosine cyclic 3',5'-monophosphate sodium salt
Purity: ≥98% (HPLC)
Citations (3)

Biological Activity for 8-Bromo-cGMP, sodium salt

8-Bromo-cGMP, sodium salt is a membrane permeable cGMP analog that activates protein kinase G (PKG). 4.3-fold more potent than cGMP in activating PKG1α and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro.

Technical Data for 8-Bromo-cGMP, sodium salt

M. Wt 446.09
Formula C10H10BrN5NaO7P
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 51116-01-9
PubChem ID 23702959
Smiles [Na+].[H][C@@]12COP([O-])(=O)O[C@@]1([H])[C@@H](O)[C@@H](O2)N1C(Br)=NC2=C1NC(N)=NC2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 8-Bromo-cGMP, sodium salt

Solvent Max Conc. mg/mL Max Conc. mM
water 44.61 100

Preparing Stock Solutions for 8-Bromo-cGMP, sodium salt

The following data is based on the product molecular weight 446.09. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.24 mL 11.21 mL 22.42 mL
5 mM 0.45 mL 2.24 mL 4.48 mL
10 mM 0.22 mL 1.12 mL 2.24 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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Product Datasheets for 8-Bromo-cGMP, sodium salt

Certificate of Analysis / Product Datasheet
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References for 8-Bromo-cGMP, sodium salt

References are publications that support the biological activity of the product.

Buchan et al (1991) Modulation of agonist-induced calcium mobilisation in bovine aortic endothelial cells by phorbol myristate acetate and cyclic AMP but not cyclic GMP. Br.J.Pharmacol. 104 361 PMID: 1665733

Ignarro et al (1974) Stimulation of phagocytic release of neutral protease from human neutrophils by cholinergic amines and cyclic 3',5'-guanosine monophosphate. J.Immunol. 112 210 PMID: 4359834

Sekhar et al (1992) Relaxation of pig coronary arteries by new and potent cGMP analogs that selectively activate type 1α, compared with type 1β, cGMP-dependent protein kinase. Mol.Pharmacol. 42 103 PMID: 1321950

If you know of a relevant reference for 8-Bromo-cGMP, sodium salt, please let us know.

Keywords: 8-Bromo-cGMP, sodium salt, 8-Bromo-cGMP, sodium salt supplier, cGMP, analog, activates, PKG, protein, kinase, G, activator, Heterotrimeric, G-protein, GTPases, Protein, Kinase, 1089, Tocris Bioscience

3 Citations for 8-Bromo-cGMP, sodium salt

Citations are publications that use Tocris products. Selected citations for 8-Bromo-cGMP, sodium salt include:

Foster et al (2014) Nitric oxide-mediated modulation of the murine locomotor network. J Neurophysiol 111 659 PMID: 24259545

Capuano et al (2009) Proinflammatory-activated trigeminal satellite cells promote neuronal sensitization: relevance for migraine pathology. Mol Pain 5 43 PMID: 19660121

Huang and Hsu (2010) Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex. Cereb Cortex 20 982 PMID: 19666830

Do you know of a great paper that uses 8-Bromo-cGMP, sodium salt from Tocris? Please let us know.

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