8-Bromo-cGMP, sodium salt

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Cat.No. 1089 - 8-Bromo-cGMP, sodium salt | C10H10BrN5NaO7P | CAS No. 51116-01-9
Description: cGMP analog; activates PKG
Chemical Name: 8-Bromoguanosine cyclic 3',5'-monophosphate sodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Membrane permeable cGMP analog that activates protein kinase G (PKG). 4.3-fold more potent than cGMP in activating PKG1α and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro.

Technical Data

M. Wt 446.09
Formula C10H10BrN5NaO7P
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 51116-01-9
PubChem ID 23702959
InChI Key ZJRFCXHKYQVNFK-YEOHUATISA-M
Smiles [Na+].[H][C@@]12COP([O-])(=O)O[C@@]1([H])[C@@H](O)[C@@H](O2)N1C(Br)=NC2=C1NC(N)=NC2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 44.61 100

Preparing Stock Solutions

The following data is based on the product molecular weight 446.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.24 mL 11.21 mL 22.42 mL
5 mM 0.45 mL 2.24 mL 4.48 mL
10 mM 0.22 mL 1.12 mL 2.24 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Buchan et al (1991) Modulation of agonist-induced calcium mobilisation in bovine aortic endothelial cells by phorbol myristate acetate and cyclic AMP but not cyclic GMP. Br.J.Pharmacol. 104 361 PMID: 1665733

Ignarro et al (1974) Stimulation of phagocytic release of neutral protease from human neutrophils by cholinergic amines and cyclic 3',5'-guanosine monophosphate. J.Immunol. 112 210 PMID: 4359834

Sekhar et al (1992) Relaxation of pig coronary arteries by new and potent cGMP analogs that selectively activate type 1α, compared with type 1β, cGMP-dependent protein kinase. Mol.Pharmacol. 42 103 PMID: 1321950


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Keywords: cGMP analog activates PKG protein kinase G activator G Protein (Heterotrimeric)

Citations for 8-Bromo-cGMP, sodium salt

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