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Potent and selective PPARδ agonist (EC50 = 1.2 nM). Displays <1000-fold selectivity over other PPAR subtypes. Increases ABC A1 transporter expression and induces apolipoprotein A1-mediated cholesterol efflux in vitro. Also increase serum HDL cholesterol and lowers small, dense LDL levels in obesity in vivo models.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 453.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.21 mL||11.03 mL||22.05 mL|
|5 mM||0.44 mL||2.21 mL||4.41 mL|
|10 mM||0.22 mL||1.1 mL||2.21 mL|
|50 mM||0.04 mL||0.22 mL||0.44 mL|
References are publications that support the biological activity of the product.
Oliver et al (2001) A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport. Proc.Natl.Acad.Sci.USA. 98 5306 PMID: 11309497
Ito et al (2016) Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance. Science 354 1156 PMID: 27738012
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Keywords: GW 501516, GW 501516 supplier, GW501516, Potent, selective, PPARδ, agonists, agonism, reverse, cholesterol, transporter, ATP-binding, cassette, A1, obesity, peroxisome, proliferator-activated, receptors, delta, PPARdelta, Receptors, 5674, Tocris Bioscience
1 Citation for GW 501516
Citations are publications that use Tocris products. Selected citations for GW 501516 include:
Guo et al (2018) Antagonism of PPAR-γ signaling expands human hematopoietic stem and progenitor cells by enhancing glycolysis. Nat Med 24 360 PMID: 29377004
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Literature in this Area
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