Selective PPARδ antagonist (IC50 values are 0.155, > 10 and ≥ 10 μM at PPARδ, PPARα and PPARγ respectively). Exhibits inverse agonist effects when administered by itself.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 418.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.39 mL||11.95 mL||23.9 mL|
|5 mM||0.48 mL||2.39 mL||4.78 mL|
|10 mM||0.24 mL||1.19 mL||2.39 mL|
|50 mM||0.05 mL||0.24 mL||0.48 mL|
References are publications that support the products' biological activity.
Shearer et al (2008) Identification and characterization of a selective peroxisome proliferator-activated receptor β/δ (NR1C2) antagonist. Mol.Endocrinol. 22 523 PMID: 17975020
Wang (2008) PPAR-δ in vascular pathophysiology. PPAR Res. 164163 PMID: 19132133
If you know of a relevant reference for GSK 0660, please let us know.
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Keywords: GSK 0660, supplier, Selective, PPARδ, PPARdelta, antagonists, Peroxisome, Proliferator-activating, Receptors, GSK0660, PPARdelta, Receptors, PPARdelta, Receptors, Tocris Bioscience
8 Citations for GSK 0660
Citations are publications that use Tocris products. Selected citations for GSK 0660 include:
Capozzi et al (2013) Peroxisome proliferator-activated receptor-β/δ regulates angiogenic cell behaviors and oxygen-induced retinopathy. Biomed Res Int 54 4197 PMID: 23716627
Ramachandran et al (2012) Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer. J Biol Chem 287 38028 PMID: 22992727
Mottillo et al (2012) Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ in brown adipocytes to match fatty acid oxidation with supply. Drug Des Devel Ther 287 25038 PMID: 22685301
Qian et al (2015) Peroxisomes in Different Skeletal Cell Types during Intramembranous and Endochondral Ossification and Their Regulation during Osteoblast Differentiation by Distinct Peroxisome Proliferator-Activated Receptors. PLoS One 10 e0143439 PMID: 26630504
Savage et al (2015) RNA-seq identifies a role for the PPARβ/δ inverse agonist GSK0660 in the regulation of TNFα-induced cytokine signaling in retinal endothelial cells. Mol Vis 21 568 PMID: 26015769
Niu et al (2015) Development of PPAR-agonist GW0742 as antidiabetic drug: study in animals. Drug Des Devel Ther 9 5625 PMID: 26508837
Lin et al (2015) Development of telmisartan in the therapy of spinal cord injury: pre-clinical study in rats. Invest Ophthalmol Vis Sci 9 4709 PMID: 26316709
Tsai et al (2014) Merit of ginseng in the treatment of heart failure in type 1-like diabetic rats. Biochem J 2014 484161 PMID: 24745017
Do you know of a great paper that uses GSK 0660 from Tocris? If so please let us know.
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