Platelet-Activating Factor (PAF) Receptors

Platelet-activating factor receptor (PAF-R) is a Gq/G11-coupled-protein receptor that has a role in a wide range of biological processes such as vasodilation, superoxide formation, cell proliferation, angiogenesis and regulation of the inflammatory response.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
3022 Edelfosine
PAF receptor agonist, also PI-PLC inhibitor
2940 PAF (C16)
Endogenous platelet-activating factor (PAF)

Antagonists

Cat No Product Name / Activity
1657 Ginkgolide B
PAF receptor antagonist
0571 PCA 4248
PAF receptor antagonist
2339 WEB 2086
Potent PAF receptor antagonist

Platelet-activating factor receptor (PAF-R) is a Gq/G11-coupled-protein receptor that has a role in a wide range of biological processes such as vasodilation, superoxide formation, cell proliferation, angiogenesis and regulation of the inflammatory response. PAF-R is linked to multiple intracellular signaling pathways, including the p38 MAPK and PI 3-K pathways, through increasing intracellular calcium mobilization, increasing IP3 synthesis and decreasing cAMP formation.

PAF-R has a wide biological distribution with high expression levels in the spleen and skeletal muscles and lower concentrations in the small intestine, lung, heart and liver. The human gene encoding the PAF-R is located on chromosome 1p35-34.3

External sources of pharmacological information for Platelet-Activating Factor (PAF) Receptors :

Literature for Platelet-Activating Factor (PAF) Receptors

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation

Platelet-Activating Factor (PAF) Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human PTAFR NM_000952 P25105
Mouse Ptafr NM_001081211 Q62035
Rat Ptafr NM_053321 P46002