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Biological Activity for ET 18-OCH3
ET 18-OCH3 is a synthetic lysophospholipid analog that selectively inhibits phosphatidylinositol phospholipase C (IC50 = 9.6 μM in fibroblasts and adenocarcinoma cells). ET 18-OCH3 acts as an agonist at platelet-activating factor (PAF) receptors. ET 18-OCH3 is an antitumor lipid that selectively induces apoptosis in tumor cells, sparing normal cells, and activates the intracellular Fas/CD95 death receptor. ETH 18-OCH3 also triggers eryptosis and interacts with mitochondrial membranes to increase mitochondrial membrane permeability, leading to dysfunction and apoptosis. Racemic mixture.
Technical Data for ET 18-OCH3
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ET 18-OCH3
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for ET 18-OCH3
The following data is based on the product molecular weight 523.73. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||9.55 mL||47.73 mL||95.47 mL|
|1 mM||1.91 mL||9.55 mL||19.09 mL|
|2 mM||0.95 mL||4.77 mL||9.55 mL|
|10 mM||0.19 mL||0.95 mL||1.91 mL|
References for ET 18-OCH3
References are publications that support the biological activity of the product.
Mollinedo et al (2004) ET-18-OCH3 (edelfosine): a selective antitumour lipid targeting apoptosis through intracellular activation of Fas/CD95 death receptor. Curr.Med.Chem. 11 3163 PMID: 15579006
Briglia et al (2015) Edelfosine induced suicidal death of human erythrocytes. Cell.Physiol.Biochem. 37 2221 PMID: 26618532
Powis et al (1992) Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues. Cancer Res. 52 2835 PMID: 1316230
Aoki et al (1995) A radioreceptor binding assay for platelet-activating factor (PAF) using membranes from CHO cells expressing human PAF receptor. J.Immunol.Methods 186 225 PMID: 7594622
Shimizu et al (2007) Roles of brain phosphatidylinositol-specific phospholipase C and diacylglycerol lipase in centrally administered histamine-induced adrenomedullary outflow in rats. Eur.J.Pharmacol. 571 138 PMID: 17628524
Wong et al (2007) Phospholipase C and myosin light chain kinase inhibition define a common step in actin regulation during cytokinesis. BMC Cell Biol. 8 15 PMID: 17509155
If you know of a relevant reference for ET 18-OCH3, please let us know.
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Citations for ET 18-OCH3
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Literature in this Area
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