Potent, selective platelet-activating factor (PAF) receptor antagonist (Ki = 16.3 nM). Displays anti-inflammatory, antiangiogenic and anticancer activity. Inhibits growth and proliferation of MCF-7 breast cancer cells.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||45.6||100mM with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 455.96. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.19 mL||10.97 mL||21.93 mL|
|5 mM||0.44 mL||2.19 mL||4.39 mL|
|10 mM||0.22 mL||1.1 mL||2.19 mL|
|50 mM||0.04 mL||0.22 mL||0.44 mL|
References are publications that support the products' biological activity.
Dent et al (1989) Characterization of PAF receptors on human neutrophils using the specific antagonist, WEB 2086. FEBS Lett. 244 365 PMID: 2537761
Sariahmetoglu et al (1998) Effects of WEB 2086 on the protective role of preconditioning against arrhythmias in rats. Pharmacol.Res. 38 173 PMID: 9782066
Cellai et al (2006) Growth inhibition and differentiation of human breast cancer cells by the PAFR antagonist WEB-2086. Br.J.Cancer 94 1637 PMID: 16721373
If you know of a relevant reference for WEB 2086, please let us know.
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Keywords: WEB 2086, supplier, Potent, PAF, receptor, antagonists, Receptors, Platelet-activating, Factor, WEB2086, Apafant, Platelet-activating, Factor, (PAF), Receptors, Platelet-activating, Factor, (PAF), Receptors, Tocris Bioscience
4 Citations for WEB 2086
Citations are publications that use Tocris products. Selected citations for WEB 2086 include:
Zhao et al (2013) Important role of platelets in modulating endotoxin-induced lung inflammation in CFTR-deficient mice. Br J Pharmacol 8 e82683 PMID: 24367540
Ajiro et al (2011) Platelet-activating factor stimulates sodium-hydrogen exchange in ventricular myocytes. PLoS One 301 H2395 PMID: 21949111
Yagnik (2014) Macrophage derived platelet activating factor implicated in the resolution phase of gouty inflammation. Int J Inflam 2014 526496 PMID: 25328755
Al-Shawaf et al (2010) Short-term stimulation of calcium-permeable transient receptor potential canonical 5-containing channels by oxidized phospholipids. Arterioscler Thromb Vasc Biol 30 1453 PMID: 20378846
Do you know of a great paper that uses WEB 2086 from Tocris? If so please let us know.
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