Neurotensin Receptors

Neurotensin (NT) is a brain and gastrointestinal peptide that acts on three subtypes of neurotensin receptors: the G-protein-coupled receptors NTS1 (high affinity) and NTS2 (low affinity) and the single transmembrane receptor NTS3 (Sortilin 1).

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
1998 JMV 449
Potent neurotensin receptor agonist
1915 Kinetensin (human)
Neurotensin-like peptide
1907 Neuromedin N (rat, mouse, porcine, canine)
Neurotensin-like peptide
1909 Neurotensin
Endogenous neurotransmitter and endocrine modulator
5087 TC NTR1 17
Selective non-peptide NTS1 agonist
2138 Xenin 8
Neurotensin-like peptide; potentiates insulin and glucagon secretion

Antagonists

Cat No Product Name / Activity
5438 NTRC 824
Potent and selective non-peptide NTS2 antagonist
2309 SR 142948
Highly potent NT receptor antagonist
3721 SR 48692
Selective non-peptide NTS1 antagonist

Neurotensin (NT) is a brain and gastrointestinal peptide that acts on three subtypes of neurotensin receptors: the G-protein-coupled receptors NTS1 (high affinity) and NTS2 (low affinity) and the single transmembrane receptor NTS3 (Sortilin 1). These receptors have many central and peripheral actions including modulation of dopaminergic transmission in nigro-striatal and mesocorticolimbic pathways, modulation of the digestive tract and hypothermic and analgesic effects.

NTS1 is distributed widely throughout the brain and gastrointestinal tract, whilst NTS2 is confined to areas of the brain involved in the descending control of nociception, including the periaqueductal gray and dorsal raphe. The human genes encoding NTS1 and NTS2 receptors are located on chromosomes 20q13 and 2p25.1 respectively.

External sources of pharmacological information for Neurotensin Receptors :

Literature for Neurotensin Receptors

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Peptide Hormone Receptors

Peptide Hormone Receptors Product Listing

A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

  • Anterior Pituitary Regulation
  • Blood Pressure Regulation
  • Feeding and Appetite Regulation
  • Glucose Regulation
  • Peptide Hormone Processing
Peptides Involved in Appetite Modulation

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Neurotensin Receptor Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
NTS1 Human NTSR1 NM_002531 P30989
Mouse Ntsr1 NM_018766 O88319
Rat Ntsr1 NM_001108967 P20789
NTS2 Human NTSR2 NM_012344 O95665
Mouse Ntsr2 NM_008747 P70310
Rat Ntsr2 NM_022695 Q58I15