TC NTR1 17

Pricing Availability Delivery Time Qty
Cat.No. 5087 - TC NTR1 17 | C27H27ClN4O5 | CAS No. 1146757-96-1
Description: Selective non-peptide NTS1 agonist
Alternative Names: ML 301
Chemical Name: N-[[1-(7-Chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl]-L-leucine
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Non-peptide neurotensin receptor 1 (NTS1) agonist (EC50 = 2-4 μM). Exhibits selectivity for NTS1 over a range of other GPCRs, including NTS2 and GPR35.

Compound Libraries

TC NTR1 17 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 522.98
Formula C27H27ClN4O5
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1146757-96-1
PubChem ID 44157038
InChI Key ZQUSYVORYNBGLG-FQEVSTJZSA-N
Smiles O=C(N[C@@H](CC(C)C)C(O)=O)C2=NN(C(C3=C(OC)C=CC=C3OC)=C2)C1=C(C=CC(Cl)=C4)C4=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 26.15 50
DMSO 52.3 100

Preparing Stock Solutions

The following data is based on the product molecular weight 522.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.91 mL 9.56 mL 19.12 mL
5 mM 0.38 mL 1.91 mL 3.82 mL
10 mM 0.19 mL 0.96 mL 1.91 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Hershberger et al (2014) Imidazole-derived agonists for the neurotensin 1 receptor. Bioorg.Med.Chem.Lett. 24 262 PMID: 24332089


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Keywords: TC NTR1 17, supplier, TCNTR117, ML301, non-peptide, selective, neurotensin, receptors, NTS1, NTR1, agonists, ML, 301, Neurotensin, Receptors, Neurotensin, Receptors, Tocris Bioscience

Citations for TC NTR1 17

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