TC NTR1 17

Pricing Availability Delivery Time Qty
Cat.No. 5087 - TC NTR1 17 | C27H27ClN4O5 | CAS No. 1146757-96-1
Description: Selective non-peptide NTS1 agonist
Alternative Names: ML 301
Chemical Name: N-[[1-(7-Chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl]-L-leucine
Purity: ≥99% (HPLC)

Biological Activity

Non-peptide neurotensin receptor 1 (NTS1) agonist (EC50 = 2-4 μM). Exhibits selectivity for NTS1 over a range of other GPCRs, including NTS2 and GPR35.

Compound Libraries

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Technical Data

M. Wt 522.98
Formula C27H27ClN4O5
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1146757-96-1
PubChem ID 44157038
Smiles O=C(N[C@@H](CC(C)C)C(O)=O)C2=NN(C(C3=C(OC)C=CC=C3OC)=C2)C1=C(C=CC(Cl)=C4)C4=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
1eq. NaOH 26.15 50
DMSO 52.3 100

Preparing Stock Solutions

The following data is based on the product molecular weight 522.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.91 mL 9.56 mL 19.12 mL
5 mM 0.38 mL 1.91 mL 3.82 mL
10 mM 0.19 mL 0.96 mL 1.91 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Hershberger et al (2014) Imidazole-derived agonists for the neurotensin 1 receptor. Bioorg.Med.Chem.Lett. 24 262 PMID: 24332089

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Keywords: TC NTR1 17, supplier, TCNTR117, ML301, non-peptide, selective, neurotensin, receptors, NTS1, NTR1, agonists, ML, 301, Neurotensin, Receptors, Neurotensin, Receptors, Tocris Bioscience

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