TC NTR1 17

Pricing Availability Delivery Time Qty
Cat.No. 5087 - TC NTR1 17 | C27H27ClN4O5 | CAS No. 1146757-96-1
Description: Selective NTS1 partial agonist
Alternative Names: ML 301 analog
Chemical Name: N-[[1-(7-Chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl]-L-leucine
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Non-peptide neurotensin receptor 1 (NTS1) partial agonist (EC50 <15.6 nM and Emax = 63% of neurotensin response in Ca2+ mobilization assay). Exhibits over 50-fold selectivity for NTS1 over NTS2 and GPR35.

Compound Libraries

TC NTR1 17 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 522.98
Formula C27H27ClN4O5
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1146757-96-1
PubChem ID 44157038
InChI Key ZQUSYVORYNBGLG-FQEVSTJZSA-N
Smiles O=C(N[C@@H](CC(C)C)C(O)=O)C2=NN(C(C3=C(OC)C=CC=C3OC)=C2)C1=C(C=CC(Cl)=C4)C4=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 52.3 100
1eq. NaOH 26.15 50

Preparing Stock Solutions

The following data is based on the product molecular weight 522.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.91 mL 9.56 mL 19.12 mL
5 mM 0.38 mL 1.91 mL 3.82 mL
10 mM 0.19 mL 0.96 mL 1.91 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Hershberger et al (2014) Imidazole-derived agonists for the neurotensin 1 receptor. Bioorg.Med.Chem.Lett. 24 262 PMID: 24332089


If you know of a relevant reference for TC NTR1 17, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Neurotensin Receptor Partial Agonists

Keywords: TC NTR1 17, TC NTR1 17 supplier, TCNTR117, ML301, analogs, non-peptide, selective, neurotensin, receptors, NTS1, NTR1, partial, agonists, ML, 301, analog, Neurotensin, Receptors, 5087, Tocris Bioscience

Citations for TC NTR1 17

Citations are publications that use Tocris products.

Currently there are no citations for TC NTR1 17. Do you know of a great paper that uses TC NTR1 17 from Tocris? Please let us know.

Reviews for TC NTR1 17

There are currently no reviews for this product. Be the first to review TC NTR1 17 and earn rewards!

Have you used TC NTR1 17?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Peptide Hormone Receptors

Peptide Hormone Receptors Product Listing

A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

  • Anterior Pituitary Regulation
  • Blood Pressure Regulation
  • Feeding and Appetite Regulation
  • Glucose Regulation
  • Peptide Hormone Processing
Peptides Involved in Appetite Modulation

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.