TC NTR1 17

Pricing Availability   Qty
Description: Selective NTS1 partial agonist
Alternative Names: ML 301 analog
Chemical Name: N-[[1-(7-Chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl]-L-leucine
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity for TC NTR1 17

TC NTR1 17 is a non-peptide neurotensin receptor 1 (NTS1) partial agonist (EC50 <15.6 nM and Emax = 63% of neurotensin response in Ca2+ mobilization assay). Exhibits over 50-fold selectivity for NTS1 over NTS2 and GPR35.

Compound Libraries for TC NTR1 17

TC NTR1 17 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TC NTR1 17

M. Wt 522.98
Formula C27H27ClN4O5
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1146757-96-1
PubChem ID 44157038
InChI Key ZQUSYVORYNBGLG-FQEVSTJZSA-N
Smiles O=C(N[C@@H](CC(C)C)C(O)=O)C2=NN(C(C3=C(OC)C=CC=C3OC)=C2)C1=C(C=CC(Cl)=C4)C4=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TC NTR1 17

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 52.3 100
1eq. NaOH 26.15 50

Preparing Stock Solutions for TC NTR1 17

The following data is based on the product molecular weight 522.98. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.91 mL 9.56 mL 19.12 mL
5 mM 0.38 mL 1.91 mL 3.82 mL
10 mM 0.19 mL 0.96 mL 1.91 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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References for TC NTR1 17

References are publications that support the biological activity of the product.

Hershberger et al (2014) Imidazole-derived agonists for the neurotensin 1 receptor. Bioorg.Med.Chem.Lett. 24 262 PMID: 24332089


If you know of a relevant reference for TC NTR1 17, please let us know.

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Keywords: TC NTR1 17, TC NTR1 17 supplier, TCNTR117, ML301, analogs, non-peptide, selective, neurotensin, receptors, NTS1, NTR1, partial, agonists, ML, 301, analog, Neurotensin, Receptors, 5087, Tocris Bioscience

Citations for TC NTR1 17

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Reviews for TC NTR1 17

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.