TC NTR1 17

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Cat.No. 5087 - TC NTR1 17 | C27H27ClN4O5 | CAS No. 1146757-96-1
Description: Selective NTS1 partial agonist
Alternative Names: ML 301 analog
Chemical Name: N-[[1-(7-Chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl]-L-leucine
Purity: ≥99% (HPLC)

Biological Activity

Non-peptide neurotensin receptor 1 (NTS1) partial agonist (EC50 <15.6 nM and Emax = 63% of neurotensin response in Ca2+ mobilization assay). Exhibits over 50-fold selectivity for NTS1 over NTS2 and GPR35.

Compound Libraries

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Technical Data

M. Wt 522.98
Formula C27H27ClN4O5
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1146757-96-1
PubChem ID 44157038
Smiles O=C(N[C@@H](CC(C)C)C(O)=O)C2=NN(C(C3=C(OC)C=CC=C3OC)=C2)C1=C(C=CC(Cl)=C4)C4=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 52.3 100
1eq. NaOH 26.15 50

Preparing Stock Solutions

The following data is based on the product molecular weight 522.98. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.91 mL 9.56 mL 19.12 mL
5 mM 0.38 mL 1.91 mL 3.82 mL
10 mM 0.19 mL 0.96 mL 1.91 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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References are publications that support the biological activity of the product.

Hershberger et al (2014) Imidazole-derived agonists for the neurotensin 1 receptor. Bioorg.Med.Chem.Lett. 24 262 PMID: 24332089

If you know of a relevant reference for TC NTR1 17, please let us know.

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