JMV 449

Pricing Availability Delivery Time Qty
Cat.No. 1998 - JMV 449 | Lys(Ψ(CH2-NH))-Lys-Pro-Tyr-Ile-Leu | CAS No. 139026-66-7
Description: Potent neurotensin receptor agonist
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent, metabolically stable neurotensin receptor agonist peptide (IC50 = 0.15 nM for inhibition of [125I]-NT binding to neonatal mouse brain; EC50 = 1.9 nM for contraction of guinea pig ileum). Produces long-lasting hypothermic, neuroprotective and analgesic effects in mice following central administration in vivo.

Technical Data

M. Wt 746.96
Formula C38H66N8O7
Sequence KKPYIL

(Modifications: Lys-1 - Lys-2 peptide bond replace with Ψ(CH2-NH))

Storage Desiccate at -20°C
CAS Number 139026-66-7
PubChem ID 164415
InChI Key TZCYVPLNMOJUIL-GULBXNHPSA-N
Smiles [H]N[C@@H](CCCCN)CN[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 0.80 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 746.96. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.34 mL 6.69 mL 13.39 mL
5 mM 0.27 mL 1.34 mL 2.68 mL
10 mM 0.13 mL 0.67 mL 1.34 mL
50 mM 0.03 mL 0.13 mL 0.27 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Lugrin et al (1991) Reduced peptide bond pseudopeptide analogues of neurotensin: binding and biological activities, and in vitro metabolic stability. Eur.J.Pharmacol. 205 191 PMID: 1812009

Dubuc et al (1992) JMV 449: a pseudopeptide analogue of neurotensin-(8-13) with highly potent and long-lasting hypothermic and analgesic effects in the mouse. Eur.J.Pharmacol. 219 327 PMID: 1425958

Torup et al (2003) Neuroprotective effect of the neurotensin analogue JMV-449 in a mouse model of permanent middle cerebral ischaemia. Neurosci.Lett. 351 173 PMID: 14623134


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Keywords: JMV 449, supplier, Potent, neurotensin, receptor, agonists, NT, Receptors, JMV449, Neurotensin, Receptors, Neurotensin, Receptors, Tocris Bioscience

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