JMV 449

Pricing Availability   Qty
Description: Potent neurotensin receptor agonist
Purity: ≥95% (HPLC)
Literature (1)

Biological Activity for JMV 449

JMV 449 is a potent, metabolically stable neurotensin receptor agonist peptide (IC50 = 0.15 nM for inhibition of [125I]-NT binding to neonatal mouse brain; EC50 = 1.9 nM for contraction of guinea pig ileum). Produces long-lasting hypothermic, neuroprotective and analgesic effects in mice following central administration in vivo.

Technical Data for JMV 449

M. Wt 746.96
Formula C38H66N8O7
Sequence KKPYIL

(Modifications: Lys-1 - Lys-2 peptide bond replaced with Ψ(CH2-NH))

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 139026-66-7
PubChem ID 164415
Smiles [H]N[C@@H](CCCCN)CN[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for JMV 449

Solubility Soluble to 0.80 mg/ml in water

Product Datasheets for JMV 449

Certificate of Analysis / Product Datasheet
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References for JMV 449

References are publications that support the biological activity of the product.

Lugrin et al (1991) Reduced peptide bond pseudopeptide analogues of neurotensin: binding and biological activities, and in vitro metabolic stability. Eur.J.Pharmacol. 205 191 PMID: 1812009

Dubuc et al (1992) JMV 449: a pseudopeptide analogue of neurotensin-(8-13) with highly potent and long-lasting hypothermic and analgesic effects in the mouse. Eur.J.Pharmacol. 219 327 PMID: 1425958

Torup et al (2003) Neuroprotective effect of the neurotensin analogue JMV-449 in a mouse model of permanent middle cerebral ischaemia. Neurosci.Lett. 351 173 PMID: 14623134

If you know of a relevant reference for JMV 449, please let us know.

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Keywords: JMV 449, JMV 449 supplier, Potent, neurotensin, receptor, agonists, NT, Receptors, JMV449, Neurotensin, 1998, Tocris Bioscience

Citations for JMV 449

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.