Potent non-peptide neurotensin (NT) receptor antagonist that binds with high affinity (IC50 = 0.32 - 3.96 nM; Ki < 10 nM). Attenuates amphetamine-induced hyperactivity and is orally active in vivo.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 685.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.46 mL||7.29 mL||14.58 mL|
|5 mM||0.29 mL||1.46 mL||2.92 mL|
|10 mM||0.15 mL||0.73 mL||1.46 mL|
|50 mM||0.03 mL||0.15 mL||0.29 mL|
References are publications that support the products' biological activity.
Gully et al (1997) Biochemical and pharmacological activities of SR 142948A, a new potent neurotensin receptor antagonist. J.Pharmacol.Exp.Ther. 280 802 PMID: 9023294
Quere et al (1998) X-ray structural characterization of SR 142948, a novel potent synthetic neurotensin receptor antagonist. Bioorg.Med.Chem.Lett. 8 653 PMID: 9871577
Marie-Claire et al (2008) Effects of the selective neurotensin antagonist SR 142948A on 3,4-methylenedioxymethamphetamine-induced behaviours in mice. Neuropharmacology 54 1107 PMID: 18410947
If you know of a relevant reference for SR 142948, please let us know.
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Keywords: SR 142948, supplier, potent, NT, receptor, antagonists, Receptors, Neurotensin, SR142948, Neurotensin, Receptors, Neurotensin, Receptors, Tocris Bioscience
3 Citations for SR 142948
Citations are publications that use Tocris products. Selected citations for SR 142948 include:
Rouibi et al (2016) Ventral Midbrain NTS1 Receptors Mediate Conditioned Reward Induced by the Neurotensin Analog, D-Tyrneurotensin. J Cereb Blood Flow Metab 9 470 PMID: 26733785
Piccart et al (2015) Neurotensin Induces Presynaptic Depression of D2 Dopamine Autoreceptor-Mediated Neurotransmission in Midbrain Dopaminergic Neurons. J Neurosci 35 11144 PMID: 26245975
Yin et al (2008) Neurotensin reduces glutamatergic transmission in the dorsolateral striatum via retrograde endocannabinoid signaling. Neuropharmacology 54 79 PMID: 17675102
Do you know of a great paper that uses SR 142948 from Tocris? If so please let us know.
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