SR 142948

Pricing Availability   Qty
Description: Highly potent NTS receptor antagonist
Chemical Name: 2-[[[5-(2,6-Dimethoxyphenyl)-1-[4-[[[3-(dimethylamino)propyl]methylamino]carbonyl]-2-(1-methylethyl)phenyl]-1H-pyrazol-3-yl]carbonyl]amino]-tricyclo[,7]decane-2-carboxylic acid
Purity: ≥97% (HPLC)
Citations (4)
Literature (1)

Biological Activity for SR 142948

SR 142948 is a potent non-peptide neurotensin (NT) receptor antagonist that binds with high affinity (IC50 = 0.32 - 3.96 nM; Ki < 10 nM). Attenuates amphetamine-induced hyperactivity and is orally active in vivo.

Compound Libraries for SR 142948

SR 142948 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SR 142948

M. Wt 685.86
Formula C39H51N5O6
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 184162-64-9
PubChem ID 5311451
Smiles COC1=CC=CC(OC)=C1C1=CC(=NN1C1=C(C=C(C=C1)C(=O)N(C)CCCN(C)C)C(C)C)C(=O)NC1(C2CC3CC(C2)CC1C3)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SR 142948

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 51.44 75
water 17.15 25

Preparing Stock Solutions for SR 142948

The following data is based on the product molecular weight 685.86. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 1.94 mL 9.72 mL 19.44 mL
3.75 mM 0.39 mL 1.94 mL 3.89 mL
7.5 mM 0.19 mL 0.97 mL 1.94 mL
37.5 mM 0.04 mL 0.19 mL 0.39 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for SR 142948

Certificate of Analysis / Product Datasheet
Select another batch:

References for SR 142948

References are publications that support the biological activity of the product.

Gully et al (1997) Biochemical and pharmacological activities of SR 142948A, a new potent neurotensin receptor antagonist. J.Pharmacol.Exp.Ther. 280 802 PMID: 9023294

Quere et al (1998) X-ray structural characterization of SR 142948, a novel potent synthetic neurotensin receptor antagonist. Bioorg.Med.Chem.Lett. 8 653 PMID: 9871577

Marie-Claire et al (2008) Effects of the selective neurotensin antagonist SR 142948A on 3,4-methylenedioxymethamphetamine-induced behaviours in mice. Neuropharmacology 54 1107 PMID: 18410947

If you know of a relevant reference for SR 142948, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Neurotensin Receptor Antagonists

Keywords: SR 142948, SR 142948 supplier, potent, NT, receptor, antagonists, Receptors, Neurotensin, SR142948, 2309, Tocris Bioscience

4 Citations for SR 142948

Citations are publications that use Tocris products. Selected citations for SR 142948 include:

Piccart et al (2015) Neurotensin Induces Presynaptic Depression of D2 DA Autoreceptor-Mediated Neurotransmission in Midbrain DArgic Neurons. J Neurosci 35 11144 PMID: 26245975

Yin et al (2008) Neurotensin reduces glutamatergic transmission in the dorsolateral striatum via retrograde endocannabinoid signaling. Neuropharmacology 54 79 PMID: 17675102

Olszewski-Hamilton and Hamilton (2011) Dependence of Relative Expression of NTR1 and EGFR on Cell Density and Extracellular pH in Human Pancreatic Cancer Cell Lines. Cancers (Basel) 3 182 PMID: 24212612

Rouibi et al (2016) Ventral Midbrain NTS1 Receptors Mediate Conditioned Reward Induced by the Neurotensin Analog, D-Tyr[11]neurotensin. J Cereb Blood Flow Metab 9 470 PMID: 26733785

Do you know of a great paper that uses SR 142948 from Tocris? Please let us know.

Reviews for SR 142948

There are currently no reviews for this product. Be the first to review SR 142948 and earn rewards!

Have you used SR 142948?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.