NTRC 824

Pricing Availability Delivery Time Qty
Cat.No. 5438 - NTRC 824 | C25H26F3N3O6S | CAS No. 1623002-61-8
Description: Potent and selective non-peptide NTS2 antagonist
Chemical Name: N-[2-[5-[[(4-Methylphenyl)sulfonyl]amino]-3-(2,2,2-trifluoroacetyl)-1H-indol-1-yl]acetyl]-L-leucine
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent and selective non-peptide neurotensin (NTS) type-2 receptor antagonist (IC50 = 38 nM). Exhibits >150-fold selectivity for NTS2 over NTS1.

Compound Libraries

NTRC 824 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 553.55
Formula C25H26F3N3O6S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1623002-61-8
PubChem ID 101873359
InChI Key SOOLLEBJNGCDOZ-FQEVSTJZSA-N
Smiles O=C(C(F)(F)F)C2=CN(CC(N[C@@H](CC(C)C)C(O)=O)=O)C1=CC=C(NS(C3=CC=C(C)C=C3)(=O)=O)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 55.35 100
ethanol 55.35 100

Preparing Stock Solutions

The following data is based on the product molecular weight 553.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.81 mL 9.03 mL 18.07 mL
5 mM 0.36 mL 1.81 mL 3.61 mL
10 mM 0.18 mL 0.9 mL 1.81 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Thomas et al (2014) Identification of N-[(5-{[(4-methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-L-leucine (NTRC-824), a neurotensin-like nonpeptide compound selective for the neurotensin receptor type 2. J.Med.Chem. 57 7472 PMID: 25157640


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Keywords: NTRC 824, supplier, NTRC824, neurotensin, receptors, NTS2, non-peptide, potent, selective, antagonists, Neurotensin, Receptors, Neurotensin, Receptors, Tocris Bioscience

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