Brain and gastrointestinal peptide with many central and peripheral functions. Acts as neuromodulator of dopamine transmission and exerts potent hypothermic and analgesic effects. Peripherally, acts as a paracrine and endocrine modulator of the digestive tract and cardiovascular system.
(Modifications: X = Glp)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 0.70 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 1672.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.6 mL||2.99 mL||5.98 mL|
|5 mM||0.12 mL||0.6 mL||1.2 mL|
|10 mM||0.06 mL||0.3 mL||0.6 mL|
|50 mM||0.01 mL||0.06 mL||0.12 mL|
References are publications that support the products' biological activity.
Binder et al (2001) Neurotensin and dopamine interactions. Pharmacol.Rev. 53 453 PMID: 11734615
Tyler-McMahon (2000) Neurotensin: peptide for the next millenium. Regul.Pept. 93 125 PMID: 11033059
Vincent et al (1999) Neurotensin and neurotensin receptors. TiPS 20 302 PMID: 10390649
If you know of a relevant reference for Neurotensin, please let us know.
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Keywords: Neurotensin, supplier, Endogenous, neurotransmitter, endocrine, modulators, NT, Receptors, Neurotensin, agonists, Neurotensin, Receptors, Neurotensin, Receptors, Tocris Bioscience
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Literature in this Area
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.