Neurotensin

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Cat.No. 1909 - Neurotensin | Glp-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu | CAS No. 39379-15-2
Description: Endogenous neurotransmitter and endocrine modulator
Datasheet
Citations

Biological Activity

Brain and gastrointestinal peptide with many central and peripheral functions. Acts as neuromodulator of dopamine transmission and exerts potent hypothermic and analgesic effects. Peripherally, acts as a paracrine and endocrine modulator of the digestive tract and cardiovascular system.

Technical Data

M. Wt 1672.94
Formula C78H121N21O20
Sequence XLYENKPRRPYIL

(Modifications: X = Glp)

Storage Desiccate at -20°C
CAS Number 39379-15-2
PubChem ID 90488724
InChI Key PCJGZPGTCUMMOT-IMEZQUPBSA-N
Smiles CC[C@@H](C)[C@@H](NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 0.70 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1672.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.6 mL 2.99 mL 5.98 mL
5 mM 0.12 mL 0.6 mL 1.2 mL
10 mM 0.06 mL 0.3 mL 0.6 mL
50 mM 0.01 mL 0.06 mL 0.12 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Binder et al (2001) Neurotensin and dopamine interactions. Pharmacol.Rev. 53 453 PMID: 11734615

Tyler-McMahon (2000) Neurotensin: peptide for the next millenium. Regul.Pept. 93 125 PMID: 11033059

Vincent et al (1999) Neurotensin and neurotensin receptors. TiPS 20 302 PMID: 10390649


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Keywords: Endogenous neurotransmitter endocrine modulators NT Receptors Neurotensin agonists Neurotensin Receptor Peptide

Citations for Neurotensin

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