ML 7 hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 4310 - ML 7 hydrochloride | C15H17IN2O2S.HCl | CAS No. 110448-33-4
Description: Selective inhibitor of myosin light chain kinase
Chemical Name: Hexahydro-1-[(5-iodo-1-naphthalenyl)sulfonyl]-1H-1,4-diazepine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (5)
Literature

Biological Activity

Selective MLCK inhibitor (Ki = 0.3 μM). Exhibits more potent inhibition than ML 9 hydrochloride (Cat. No. 0431) Displays reversible, ATP-competitive inhibition of Ca2+-calmodulin-dependent and -independent smooth muscle MLCKs. Inhibits proplatelet formation and stabilization.

Technical Data

M. Wt 452.74
Formula C15H17IN2O2S.HCl
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 110448-33-4
PubChem ID 9803932
InChI Key KDDALCDYHZIZMH-UHFFFAOYSA-N
Smiles IC1=C(C=CC=C2S(N3CCCNCC3)(=O)=O)C2=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.64 50

Preparing Stock Solutions

The following data is based on the product molecular weight 452.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.21 mL 11.04 mL 22.09 mL
5 mM 0.44 mL 2.21 mL 4.42 mL
10 mM 0.22 mL 1.1 mL 2.21 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Saitoh et al (1987) Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase. J.Biol.Chem. 262 7796 PMID: 3108259

Meinders et al (2015) Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function. Blood 125 1957 PMID: 25538045


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Keywords: ML7 HCl MLC kinase inhibitor inhibits myosin light chain kinase inhibitors MLCKs platelets Myosin Light Chain Kinase

5 Citations for ML 7 hydrochloride

Citations are publications that use Tocris products. Selected citations for ML 7 hydrochloride include:

Bharadwaj (2017) αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin. Nat Commun 8 14348 PMID: 28128308

Ets (2016) Sustained Contraction in Vascular Smooth Muscle by Activation of L-type Ca2+ Channels Does Not Involve Ca2+ Sensitization or Caldesmon. Front Pharmacol 7 516 PMID: 28082901

Leoni et al (2015) Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. J Clin Invest 125 1215 PMID: 25664854

Chaudhuri et al (2015) Substrate stress relaxation regulates cell spreading. J Neurosci 6 6364 PMID: 25695512

Siddoway et al (2013) An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling. Am J Physiol Renal Physiol 33 11206 PMID: 23825423


Do you know of a great paper that uses ML 7 hydrochloride from Tocris? If so please let us know.

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Literature in this Area

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Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

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Pathways for ML 7 hydrochloride

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