Melanin-concentrating Hormone Receptors

Melanin-concentrating hormone (MCH) is a neuropeptide that is expressed in the central and peripheral nervous systems and plays an important role in the control of feeding behaviors and energy metabolism. MCH acts on two GPCRs: MCH1 (GPR24) and MCH2 (GPR145).

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
3806 MCH (human, mouse, rat)
Potent endogenous MCH agonist
3434 [Ala17]-MCH
Potent MCH receptor agonist

Antagonists

Cat No Product Name / Activity
3359 ATC 0065
Potent and selective MCH1 antagonist
3346 ATC 0175 hydrochloride
MCH1 antagonist; also 5-HT2B antagonist and 5-HT1A partial agonist
4242 GW 803430
MCH1 antagonist
3347 SNAP 94847 hydrochloride
Potent and selective MCH1 antagonist
4365 TC-MCH 7c
Selective melanin-concentrating hormone receptor 1 (MCH1R) antagonist

Melanin-concentrating hormone (MCH) is a neuropeptide that is expressed in the central and peripheral nervous systems and plays an important role in the control of feeding behaviors and energy metabolism. MCH acts on two GPCRs: MCH1 (GPR24) and MCH2 (GPR145).

MCH1 and MCH2 have very similar tissue distribution patterns and are expressed in many brain regions, particularly the ventromedial, dorsalmedial and arcuate nuclei of the hypothalamus and zona incerta. They are also found at lower levels in the periphery including in the pituitary gland, adipose tissue and pancreas. MCH1 is a target for the orexigenic peptide leptin, which supports a role for MCH receptors in the control of food intake and energy expenditure. The human genes encoding MCH1 and MCH2 are localized to chromosomes 22q13.3 and 6q21 respectively. MCH2 is a pseudogene in rodents.

External sources of pharmacological information for Melanin-concentrating Hormone Receptors :

    Literature for Melanin-concentrating Hormone Receptors

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    Melanin-concentrating Hormone Receptor Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    MCH1 Human MCHR1 NM_005297 Q99705
    Mouse Mchr1 NM_145132 Q8JZL2
    Rat Mchr1 NM_031758 P97639
    MCH2 Human MCHR2 NM_032503 Q969V1