GW 803430

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Cat.No. 4242 - GW 803430 | C25H24ClN3O3S | CAS No. 515141-51-2
Description: MCH1 antagonist
Chemical Name: 6-(4-Chlorophenyl)-3-[3-methoxy-4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-thieno[3,2-d]pyrimidin-4(3H)-one
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective melanin-concentrating hormone receptor 1 (MCH1) antagonist (IC50 = 9.3 nM). Displays antiobesity and antidepressant-like effects in rats and mice. Orally active.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Technical Data

M. Wt 481.99
Formula C25H24ClN3O3S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 515141-51-2
PubChem ID 9826520
InChI Key MWULMTACIBZPGN-UHFFFAOYSA-N
Smiles ClC(C=C3)=CC=C3C(S2)=CC1=C2C(N(C4=CC(OC)=C(OCCN5CCCC5)C=C4)C=N1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 14.75 25

Preparing Stock Solutions

The following data is based on the product molecular weight 481.99. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 8.3 mL 41.49 mL 82.99 mL
1.25 mM 1.66 mL 8.3 mL 16.6 mL
2.5 mM 0.83 mL 4.15 mL 8.3 mL
12.5 mM 0.17 mL 0.83 mL 1.66 mL

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References

References are publications that support the biological activity of the product.

Rivera et al (2008) Melanin-concentrating hormone receptor 1 antagonists: a new perspective for the pharmacologic treatment of obesity. Curr.Med.Chem. 15 1025 PMID: 18393860

Gehlert et al (2009) Preclinical evaluation of melanin-concentrating hormone receptor 1 antagonism for the treatment of obesity and depression. J.Pharmacol.Exp.Ther. 329 429 PMID: 19182070


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Citations for GW 803430

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