SNAP 94847 hydrochloride

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Description: Potent and selective MCH1 antagonist
Chemical Name: N-[3-[1-[[4-(3,4-Difluorophenoxy)phenyl]methyl]-4-piperidinyl]-4-methylphenyl]-2-methylpropanamide hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)

Biological Activity for SNAP 94847 hydrochloride

SNAP 94847 hydrochloride is a potent melanin-concentrating hormone receptor 1 (MCH1) antagonist (Ki = 2.2 nM, KD = 530 pM) that displays > 80-fold and > 500-fold selectivity over α1A and D2 receptors respectively. Increases neurogenesis in the dentate gyrus and decreases food-reinforced operant responding in vivo. Exhibits anxiolytic activity and is orally active.

Compound Libraries for SNAP 94847 hydrochloride

SNAP 94847 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SNAP 94847 hydrochloride

M. Wt 515.03
Formula C29H32F2N2O2.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1781934-47-1
PubChem ID 56972235
InChI Key DEDUDFNRQKUBRH-UHFFFAOYSA-N
Smiles CC1=CC=C(NC(C(C)C)=O)C=C1C(CC4)CCN4CC(C=C3)=CC=C3OC2=CC(F)=C(F)C=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SNAP 94847 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 51.5 100
ethanol 51.5 100

Preparing Stock Solutions for SNAP 94847 hydrochloride

The following data is based on the product molecular weight 515.03. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.94 mL 9.71 mL 19.42 mL
5 mM 0.39 mL 1.94 mL 3.88 mL
10 mM 0.19 mL 0.97 mL 1.94 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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Product Datasheets for SNAP 94847 hydrochloride

Certificate of Analysis / Product Datasheet
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View Related Products by Product Action

View all Melanin-concentrating Hormone Receptor Antagonists

Keywords: SNAP 94847 hydrochloride, SNAP 94847 hydrochloride supplier, Potent, selective, MCH1, antagonists, Melanin-concentrating, Hormone, Receptors, SNAP94847, hydrochloride, MCHR1, MCH1R, 487051-12-7, 3347, Tocris Bioscience

1 Citation for SNAP 94847 hydrochloride

Citations are publications that use Tocris products. Selected citations for SNAP 94847 hydrochloride include:

Kim and Han (2016) Physical Exercise Counteracts Stress-induced Upregulation of Melanin-concentrating Hormone in the Brain and Stress-induced Persisting Anxiety-like Behaviors. Exp Neurobiol 25 163 PMID: 27574483


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Reviews for SNAP 94847 hydrochloride

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.