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Cat.No. 4365 - TC-MCH 7c | C24H25FN2O3 | CAS No. 864756-35-4
Description: Selective melanin-concentrating hormone receptor 1 (MCH1R) antagonist
Chemical Name: 4-[(4-Fluorophenyl)methoxy]-1-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-2(1H)-pyridinone
Purity: ≥97% (HPLC)
Literature (4)

Biological Activity for TC-MCH 7c

TC-MCH 7c is a potent, selective melanin-concentrating hormone receptor 1 (MCH1R) antagonist (IC50= 5.6 nM in hMCH1R-expressing CHO cells). Displays selectivity for MCH1R over MCH2R (IC50 = > 10 μM). Decreases body weight in a mouse model of diet-induced obesity. Brain penetrant; orally active.

Technical Data for TC-MCH 7c

M. Wt 408.47
Formula C24H25FN2O3
Storage Store at RT
Purity ≥97% (HPLC)
CAS Number 864756-35-4
PubChem ID 11654412

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TC-MCH 7c

Solvent Max Conc. mg/mL Max Conc. mM
1eq. HCl 40.85 100
DMSO 20.42 50

Preparing Stock Solutions for TC-MCH 7c

The following data is based on the product molecular weight 408.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.45 mL 12.24 mL 24.48 mL
5 mM 0.49 mL 2.45 mL 4.9 mL
10 mM 0.24 mL 1.22 mL 2.45 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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Product Datasheets for TC-MCH 7c

Certificate of Analysis / Product Datasheet
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References for TC-MCH 7c

References are publications that support the biological activity of the product.

Haga et al (2011) Discovery of novel phenylpyridone derivatives as potent and selective MCH1R antagonists. Bioorg.Med.Chem. 19 883 PMID: 21190859

Ito et al (2009) Melanin-concentrating hormone 1-receptor antagonist suppresses body weight gain correlated with high receptor occupancy levels in diet-induced obesity mice. Eur.J.Pharmacol. 624 77 PMID: 19836369

If you know of a relevant reference for TC-MCH 7c, please let us know.

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