MCH (human, mouse, rat)

Pricing Availability   Qty
Description: Potent endogenous MCH agonist
Alternative Names: Melanin-concentrating hormone (human, mouse, rat)
Purity: ≥95% (HPLC)
Datasheet
Citations (6)
Reviews
Literature (2)

Biological Activity for MCH (human, mouse, rat)

MCH (human, mouse, rat) is a potent endogenous agonist at melanin-concentration hormone (MCH) receptors (IC50 values are 0.3 and 1.5 nM and EC50 values are 3.9 and 0.1 nM at MCH1 and MCH2 receptors respectively). Increases food intake in vivo.

Technical Data for MCH (human, mouse, rat)

M. Wt 2386.84
Formula C105H160N30O26S4
Sequence DFDMLRCMLGRVYRPCWQV

(Modification: Disulfide bridge: 7-16)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 128315-56-0
PubChem ID 24868207
InChI Key MWLPXSMFEPHETN-QRXCLJFASA-N
Smiles [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MCH (human, mouse, rat)

Solubility Soluble to 1 mg/ml in water

Product Datasheets for MCH (human, mouse, rat)

Certificate of Analysis / Product Datasheet
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References for MCH (human, mouse, rat)

References are publications that support the biological activity of the product.

Sailer et al (2001) Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. Proc.Natl.Acad.Sci.USA 98 7564


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Reviews for MCH (human, mouse, rat)

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.