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Submit ReviewMCH (human, mouse, rat)
Description: Potent endogenous MCH agonist
Alternative Names: Melanin-concentrating hormone (human, mouse, rat)
Purity: ≥95% (HPLC)
Biological Activity for MCH (human, mouse, rat)
MCH (human, mouse, rat) is a potent endogenous agonist at melanin-concentration hormone (MCH) receptors (IC50 values are 0.3 and 1.5 nM and EC50 values are 3.9 and 0.1 nM at MCH1 and MCH2 receptors respectively). Increases food intake in vivo.
Technical Data for MCH (human, mouse, rat)
| M. Wt | 2386.84 |
| Formula | C105H160N30O26S4 |
| Sequence |
DFDMLRCMLGRVYRPCWQV (Modification: Disulfide bridge: 7-16) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 128315-56-0 |
| PubChem ID | 24868207 |
| InChI Key | MWLPXSMFEPHETN-QRXCLJFASA-N |
| Smiles | [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for MCH (human, mouse, rat)
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for MCH (human, mouse, rat)
References for MCH (human, mouse, rat)
References are publications that support the biological activity of the product.
Sailer et al (2001) Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. Proc.Natl.Acad.Sci.USA 98 7564
If you know of a relevant reference for MCH (human, mouse, rat), please let us know.
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Keywords: MCH (human, mouse, rat), MCH (human, mouse, rat) supplier, potent, endogenous, MCH, agonists, receptors, melanin-concentration, hormone, MCH1, MCH2, MCH2R, MCHR2, MCH1R, MCHR1, Melanin-concentrating, Melanin, concentrating, concentration, (human,, mouse,, rat), Hormone, Receptors, 3806, Tocris Bioscience
3 Citations for MCH (human, mouse, rat)
Citations are publications that use Tocris products. Selected citations for MCH (human, mouse, rat) include:
Jang (2018) Novel analgesic effects of melanin-concentrating hormone on persistent neuropathic and inflammatory pain in mice. Sci Rep 8 707 PMID: 29335480
Nøhr et al (2017) The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW. Neurochem Int 102 105 PMID: 27916541
Kim and Han (2016) Functional Connectivity of Basolateral Amygdala Neurons Carrying Orexin Receptors and Melanin-concentrating Hormone Receptors in Regulating Sociability and Mood-related Behaviors. Exp Neurobiol 25 307 PMID: 28035181
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