MCH (human, mouse, rat)

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Cat.No. 3806 - MCH (human, mouse, rat) | Asp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Tyr-Arg-Pro-Cys-Trp-Gln-Val (Disulfide Bridge = 7-16) | CAS No. 128315-56-0
Description: Potent endogenous MCH agonist
Alternative Names: Melanin-concentrating hormone (human, mouse, rat)
Datasheet
Citations (3)
Reviews
Literature (4)

Biological Activity for MCH (human, mouse, rat)

MCH (human, mouse, rat) is a potent endogenous agonist at melanin-concentration hormone (MCH) receptors (IC50 values are 0.3 and 1.5 nM and EC50 values are 3.9 and 0.1 nM at MCH1 and MCH2 receptors respectively). Increases food intake in vivo.

Technical Data for MCH (human, mouse, rat)

M. Wt 2386.84
Formula C105H160N30O26S4
Sequence DFDMLRCMLGRVYRPCWQV

(Modifications: Disulfide bridge between 7-16)

Storage Store at -20°C
CAS Number 128315-56-0
PubChem ID 24868207
InChI Key MWLPXSMFEPHETN-QRXCLJFASA-N
Smiles [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MCH (human, mouse, rat)

Solubility Soluble to 1 mg/ml in water

Product Datasheets for MCH (human, mouse, rat)

Certificate of Analysis / Product Datasheet
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References for MCH (human, mouse, rat)

References are publications that support the biological activity of the product.

Sailer et al (2001) Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. Proc.Natl.Acad.Sci.USA 98 7564


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Keywords: MCH (human, mouse, rat), MCH (human, mouse, rat) supplier, potent, endogenous, MCH, agonists, receptors, melanin-concentration, hormone, MCH1, MCH2, MCH2R, MCHR2, MCH1R, MCHR1, Melanin-concentrating, Melanin, concentrating, concentration, (human,, mouse,, rat), Hormone, Receptors, 3806, Tocris Bioscience

3 Citations for MCH (human, mouse, rat)

Citations are publications that use Tocris products. Selected citations for MCH (human, mouse, rat) include:

Jang (2018) Novel analgesic effects of melanin-concentrating hormone on persistent neuropathic and inflammatory pain in mice. Sci Rep 8 707 PMID: 29335480

Nøhr et al (2017) The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW. Neurochem Int 102 105 PMID: 27916541

Kim and Han (2016) Functional Connectivity of Basolateral Amygdala Neurons Carrying Orexin Receptors and Melanin-concentrating Hormone Receptors in Regulating Sociability and Mood-related Behaviors. Exp Neurobiol 25 307 PMID: 28035181


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