MCH (human, mouse, rat)

Pricing Availability Delivery Time Qty
Cat.No. 3806 - MCH (human, mouse, rat) | Asp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Tyr-Arg-Pro-Cys-Trp-Gln-Val (Disulfide Bridge = 7-16) | CAS No. 128315-56-0
Description: Potent endogenous MCH agonist
Alternative Names: Melanin-concentrating hormone (human, mouse, rat)
Datasheet
Citations
Literature

Biological Activity

Potent endogenous agonist at melanin-concentration hormone (MCH) receptors (IC50 values are 0.3 and 1.5 nM and EC50 values are 3.9 and 0.1 nM at MCH1 and MCH2 receptors respectively). Increases food intake in vivo.

Technical Data

M. Wt 2386.84
Formula C105H160N30O26S4
Sequence DFDMLRCMLGRVYRPCWQV

(Modifications: Disulfide bridge between 7-16)

Storage Store at -20°C
CAS Number 128315-56-0
PubChem ID 24868207
InChI Key MWLPXSMFEPHETN-QRXCLJFASA-N
Smiles [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 2386.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.42 mL 2.09 mL 4.19 mL
5 mM 0.08 mL 0.42 mL 0.84 mL
10 mM 0.04 mL 0.21 mL 0.42 mL
50 mM 0.01 mL 0.04 mL 0.08 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Sailer et al (2001) Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. Proc.Natl.Acad.Sci.USA 98 7564 PMID:


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Citations for MCH (human, mouse, rat)

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Pathways for MCH (human, mouse, rat)

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