Ionophores

Ionophores are lipid soluble molecules that increase the permeability of an ion across a biological membrane. They 'shield' the ion, enabling it to transverse hydrophobic biological membranes. There are two types; mobile ion carriers and channel-forming ionophores.

Products
Background
Literature
Cat No Product Name / Activity
1234 A23187, free acid
Calcium ionophore
1704 Ionomycin calcium salt
Calcium ionophore
2092 Ionomycin free acid
Calcium ionophore
5223 Monensin sodium salt
Sodium ionophore; antibacterial agent
4312 Nigericin sodium salt
Selective K+ ionophore
2505 Nonactin
Monovalent cation ionophore
3373 Valinomycin
Selective K+ ionophore

Ionophores are lipid soluble molecules that increase the permeability of a given ion across a biological membrane. They create a shield over the ion, enabling it to transverse hydrophobic biological membranes.

There are two types of ionophores; mobile ion carriers, which are small molecules that physically shield the ion from the surrounding environment and facilitate its movement across the plasma membrane, and channel-forming ionophores, which create a pore in the biological membrane to allow the ion to pass through. These molecules can act to disrupt transmembrane ion concentrations and often have antibiotic properties.

Literature for Ionophores

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New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells