Ionomycin free acid

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Cat.No. 2092 - Ionomycin free acid | C41H72O9 | CAS No. 56092-81-0
Description: Calcium ionophore
Chemical Name: (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-10,16-docosadienoic acid
Datasheet
Citations

Biological Activity

Calcium ionophore; more specific than A23187 (Cat. No. 1234).

Technical Data

M. Wt 709.01
Formula C41H72O9
Storage Desiccate at -20°C
CAS Number 56092-81-0
PubChem ID 6912226
InChI Key PGHMRUGBZOYCAA-ADZNBVRBSA-N
Smiles O=C(O)CC[C@@H](C)C[C@H](C)C[C@H](C)C(/C=C(O)/[C@H](C)C[C@@H](C/C=C/[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]1CC[C@]([C@]2([H])O[C@@]([C@H](O)C)(C)CC2)(C)O1)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.09 10
ethanol 7.09 10

Preparing Stock Solutions

The following data is based on the product molecular weight 709.01. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.41 mL 7.05 mL 14.1 mL
5 mM 0.28 mL 1.41 mL 2.82 mL
10 mM 0.14 mL 0.71 mL 1.41 mL
50 mM 0.03 mL 0.14 mL 0.28 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Liu and Hermann (1978) Characterization of ionomycin as a calcium ionophore. J.Biol.Chem. 253 5892 PMID: 28319

Kaufmann et al (1980) Cation transport and specificity of ionomycin. Comparison with ionophore A23187 in rat liver mitochondria. J.Biol.Chem. 255 2735 PMID: 6766939

Elzi et al (2001) Ionomycin causes activation of p38 and p42/44 mitogen-activated protein kinases in human neutrophils. Am.J.Physiol.Cell Physiol. 281 C350 PMID: 11401859


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