Ionomycin calcium salt

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Cat.No. 1704 - Ionomycin calcium salt | C41H70O9.Ca | CAS No. 56092-82-1
Description: Calcium ionophore
Chemical Name: (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-10,16-docosadienoic acid calcium salt
Purity: ≥98% (HPLC)
Datasheet
Citations (8)

Biological Activity

Calcium ionophore; more specific than A23187 (Cat. No. 1234).

Technical Data

M. Wt 747.08
Formula C41H70O9.Ca
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 56092-82-1
PubChem ID 6446270
InChI Key WKRWUYKLUMMAKG-WYGBAUISSA-L
Smiles O=C([O-])CC[C@@H](C)C[C@H](C)C[C@H](C)C(/C=C([O-])/[C@H](C)C[C@@H](C/C=C/[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]1CC[C@]([C@]2([H])O[C@@]([C@H](O)C)(C)CC2)(C)O1)C)=O.[Ca+2]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.68 25mM with gentle warming
ethanol 74.71 100

Preparing Stock Solutions

The following data is based on the product molecular weight 747.08. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.34 mL 6.69 mL 13.39 mL
5 mM 0.27 mL 1.34 mL 2.68 mL
10 mM 0.13 mL 0.67 mL 1.34 mL
50 mM 0.03 mL 0.13 mL 0.27 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Elzi et al (2001) Ionomycin causes activation of p38 and p42/44 mitogen-activated protein kinases in human neutrophils. Am.J.Physiol.Cell Physiol. 281 C350 PMID: 11401859

Kaufmann et al (1980) Cation transport and specificity of ionomycin. Comparison with ionophore A23187 in rat liver mitochondria. J.Biol.Chem. 255 2735 PMID: 6766939

Liu and Hermann (1978) Characterization of ionomycin as a calcium ionophore. J.Biol.Chem. 253 5892 PMID: 28319


If you know of a relevant reference for Ionomycin calcium salt, please let us know.

Keywords: Ionomycin calcium salt, supplier, Calcium, ionophore, Ca2+, Ionophore, Signaling, Signalling, Agents, General, antibiotics, General, Calcium, Signaling, Agents, Ionophores, Antibiotics, General, Calcium, Signaling, Agents, Tocris Bioscience

8 Citations for Ionomycin calcium salt

Citations are publications that use Tocris products. Selected citations for Ionomycin calcium salt include:

Soltoff and Lannon (2013) Activation of ERK1/2 by store-operated calcium entry in rat parotid acinar cells. PLoS One 8 e72881 PMID: 24009711

Barcomb et al (2013) Enzymatic activity of CaMKII is not required for its interaction with the glutamate receptor subunit GluN2B. Mol Pharmacol 84 834 PMID: 24056996

Selway et al (2012) Evidence that Ca2+ within the microdomain of the L-type voltage gated Ca2+ channel activates ERK in MIN6 cells in response to glucagon-like peptide-1. PLoS One 7 e33004 PMID: 22412973

Ohya et al (2011) Involvement of dominant-negative spliced variants of the intermediate conductance Ca2+-activated K+ channel, K(Ca)3.1, in immune function of lymphoid cells. J Biol Chem 286 16940 PMID: 21345794

Plog et al (2015) Naturally Occurring Deletion Mutants of the Pig-Specific, Intestinal Crypt Epithelial Cell Protein CLCA4b without Apparent Phenotype. PLoS One 10 e0140050 PMID: 26474299

Shambharkar et al (2015) TMEM203 Is a Novel Regulator of Intracellular Calcium Homeostasis and Is Required for Spermatogenesis. MBio 10 e0127480 PMID: 25996873

Azab et al (2015) Binding of αherpesvirus Glycoprotein H to Surface α4β1-Integrins Activates Calcium-Signaling Pathways and Induces Phosphatidylserine Exposure on the Plasma Membrane. PLoS One 6 PMID: 26489864

Jonas et al (2015) Assessment of TTX-s and TTX-r Action Potential Conduction along Neurites of NGF and GDNF Cultured Porcine DRG Somata. J Pharmacol Exp Ther 10 e0139107 PMID: 26407014


Do you know of a great paper that uses Ionomycin calcium salt from Tocris? If so please let us know.

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