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Biological Activity for Valinomycin
Valinomycin is a selective K+ ionophore (K0.5 values are 48, 73, 75, 93 and 246 mM for K+, Rb+, Cs+, Na+ and Li+ respectively) that transports K+ across biological and artificial lipid membranes. Inhibits Ca2+-ATPase activity and induces apoptosis through mitochondrial membrane depolarization, caspase-3 activation and phosphatidylserine translocation in vitro.
Technical Data for Valinomycin
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Valinomycin
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Valinomycin
The following data is based on the product molecular weight 1111.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.25 mM||3.6 mL||18 mL||35.99 mL|
|1.25 mM||0.72 mL||3.6 mL||7.2 mL|
|2.5 mM||0.36 mL||1.8 mL||3.6 mL|
|12.5 mM||0.07 mL||0.36 mL||0.72 mL|
References for Valinomycin
References are publications that support the biological activity of the product.
Davidson and Berman (1985) Interaction of valinomycin and monovalent cations with the (Ca2+,Mg2+)-ATPase of skeletal muscle sarcoplasmic reticulum. J.Biol.Chem. 260 7325 PMID: 3158656
Abdalah et al (2006) Valinomycin-induced apoptosis in Chinese hamster ovary cells. Neurosci.Letts. 405 68
Rose and Jenkins (2007) The effects of the ionophore valinomycin on biomimetic solid supported lipid DPPTE/EPC membranes. Bioelectrochem. 70 387
If you know of a relevant reference for Valinomycin, please let us know.
Keywords: Valinomycin, Valinomycin supplier, Selective, K+, ionophores, Potassium, antibiotics, Ionophores, Antibiotics, 3373, Tocris Bioscience
3 Citations for Valinomycin
Citations are publications that use Tocris products. Selected citations for Valinomycin include:
Cassilly et al (2016) SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A. J Cancer 11 e0154932 PMID: 27183222
MacDonald et al (2019) A nanoscale, multi-parametric flow cytometry-based platform to study mitochondrial heterogeneity and mitochondrial DNA dynamics. Commun Biol 2 258 PMID: 31312727
Yin et al (2018) The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis. Nat Commun 9 2815 PMID: 30022023
Do you know of a great paper that uses Valinomycin from Tocris? Please let us know.
Reviews for Valinomycin
Average Rating: 4.5 (Based on 2 Reviews.)
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Biologically active compounds that have been documented to interact with awide range of targets including SB-224289 (Cat. # 1221), MG-624 (Cat.# 1356), GVIA (Cat. No. 1085), DPAT hydrobromide (Cat. No. 1080) and valinomycin (VA; Cat. # 3373) were ordered from Tocris Bioscience