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Cat.No. 3373 - Valinomycin | C54H90N6O18 | CAS No. 2001-95-8
Description: Selective K+ ionophore
Chemical Name: Cyclo(D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl)
Citations (1)

Biological Activity

Selective K+ ionophore (K0.5 values are 48, 73, 75, 93 and 246 mM for K+, Rb+, Cs+, Na+ and Li+ respectively) that transports K+ across biological and artificial lipid membranes. Inhibits Ca2+-ATPase activity and induces apoptosis through mitochondrial membrane depolarization, caspase-3 activation and phosphatidylserine translocation in vitro.

Technical Data

M. Wt 1111.32
Formula C54H90N6O18
Storage Desiccate at -20°C
CAS Number 2001-95-8
PubChem ID 3000706
Smiles O=C([C@H](C)OC([C@@H]([C@@H](C)C)NC([C@H](OC([C@@H](NC([C@@H](O1)C)=O)[C@@H](C)C)=O)[C@@H](C)C)=O)=O)N[C@@H]([C@@H](C)C)C(O[C@H]([C@@H](C)C)C(N[C@@H](C(O[C@@H](C)C(N[C@@H]([C@H](C)C)C(O[C@H]([C@@H](C)C)C(N[C@H]([C@H](C)C)C1=O)=O)=O)=O)=O)[C@H](C)C)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 27.78 25
ethanol 27.78 25

Preparing Stock Solutions

The following data is based on the product molecular weight 1111.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 3.6 mL 18 mL 35.99 mL
1.25 mM 0.72 mL 3.6 mL 7.2 mL
2.5 mM 0.36 mL 1.8 mL 3.6 mL
12.5 mM 0.07 mL 0.36 mL 0.72 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Davidson and Berman (1985) Interaction of valinomycin and monovalent cations with the (Ca2+,Mg2+)-ATPase of skeletal muscle sarcoplasmic reticulum. J.Biol.Chem. 260 7325 PMID: 3158656

Abdalah et al (2006) Valinomycin-induced apoptosis in Chinese hamster ovary cells. Neurosci.Letts. 405 68

Rose and Jenkins (2007) The effects of the ionophore valinomycin on biomimetic solid supported lipid DPPTE/EPC membranes. Bioelectrochem. 70 387

If you know of a relevant reference for Valinomycin, please let us know.

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Keywords: Valinomycin, Valinomycin supplier, Selective, K+, ionophores, Potassium, antibiotics, Ionophores, Antibiotics, 3373, Tocris Bioscience

1 Citation for Valinomycin

Citations are publications that use Tocris products. Selected citations for Valinomycin include:

Cassilly et al (2016) SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A. J Cancer 11 e0154932 PMID: 27183222

Do you know of a great paper that uses Valinomycin from Tocris? Please let us know.

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