Valinomycin

Pricing Availability Delivery Time Qty
Cat.No. 3373 - Valinomycin | C54H90N6O18 | CAS No. 2001-95-8
Description: Selective K+ ionophore
Chemical Name: Cyclo(D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl)
Datasheet
Citations (1)
Literature

Biological Activity

Selective K+ ionophore (K0.5 values are 48, 73, 75, 93 and 246 mM for K+, Rb+, Cs+, Na+ and Li+ respectively) that transports K+ across biological and artificial lipid membranes. Inhibits Ca2+-ATPase activity and induces apoptosis through mitochondrial membrane depolarization, caspase-3 activation and phosphatidylserine translocation in vitro.

Technical Data

M. Wt 1111.32
Formula C54H90N6O18
Storage Desiccate at -20°C
CAS Number 2001-95-8
PubChem ID 3000706
InChI Key FCFNRCROJUBPLU-DNDCDFAISA-N
Smiles O=C([C@H](C)OC([C@@H]([C@@H](C)C)NC([C@H](OC([C@@H](NC([C@@H](O1)C)=O)[C@@H](C)C)=O)[C@@H](C)C)=O)=O)N[C@@H]([C@@H](C)C)C(O[C@H]([C@@H](C)C)C(N[C@@H](C(O[C@@H](C)C(N[C@@H]([C@H](C)C)C(O[C@H]([C@@H](C)C)C(N[C@H]([C@H](C)C)C1=O)=O)=O)=O)=O)[C@H](C)C)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.78 25
ethanol 27.78 25

Preparing Stock Solutions

The following data is based on the product molecular weight 1111.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.9 mL 4.5 mL 9 mL
5 mM 0.18 mL 0.9 mL 1.8 mL
10 mM 0.09 mL 0.45 mL 0.9 mL
50 mM 0.02 mL 0.09 mL 0.18 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Davidson and Berman (1985) Interaction of valinomycin and monovalent cations with the (Ca2+,Mg2+)-ATPase of skeletal muscle sarcoplasmic reticulum. J.Biol.Chem. 260 7325 PMID: 3158656

Abdalah et al (2006) Valinomycin-induced apoptosis in Chinese hamster ovary cells. Neurosci.Letts. 405 68 PMID:

Rose and Jenkins (2007) The effects of the ionophore valinomycin on biomimetic solid supported lipid DPPTE/EPC membranes. Bioelectrochem. 70 387 PMID:


If you know of a relevant reference for Valinomycin, please let us know.

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Keywords: Valinomycin, supplier, Selective, K+, ionophores, Potassium, antibiotics, Ionophores, Tocris Bioscience

1 Citation for Valinomycin

Citations are publications that use Tocris products. Selected citations for Valinomycin include:

Cassilly et al (2016) SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A. J Cancer 11 e0154932 PMID: 27183222


Do you know of a great paper that uses Valinomycin from Tocris? If so please let us know.

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Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for Valinomycin

Protocols

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