Nigericin sodium salt

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Description: Selective K+ ionophore
Chemical Name: (2R)-2-[(2R,3S,6R)-6-[[(2S,4R,5R,7R,9R,10R)- 2-[(2R,5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-Hydroxy- 6-(hydroxymethyl)-3,5-dimethyl-2-tetrahydropyranyl]-3-methyl- 2-tetrahydrofuranyl]-5-methyl-2-tetrahydrofuranyl]-9-methoxy- 2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl]methyl]-3-methyl- 2-tetrahydropyranyl]propanoic acid sodium salt
Datasheet
Citations (8)
Reviews
Literature (1)

Biological Activity for Nigericin sodium salt

Nigericin sodium salt is a potassium ionophore, exchanges K+ for H+ across biological membranes, in a similar manner to Valinomycin (Cat. No. 3373). Stimulates mitochondral ATPase activity and disrupts membrane potential. Also acts as an ionophore for Pb2+ with no activity with other divalent cations. Antibiotic derived from Streptomyces hygroscopius.

Technical Data for Nigericin sodium salt

M. Wt 746.94
Formula C40H67NaO11
Storage Store at -20°C
CAS Number 28643-80-3
PubChem ID 16760591
InChI Key MOYOTUKECQMGHE-PDEFJWSRSA-M
Smiles [Na+].[H][C@@]1(C[C@H](C)[C@@]([H])(O1)[C@]1(C)CC[C@@]([H])(O1)[C@]1(C)C[C@@H](C)[C@]2(O1)O[C@]([H])(C[C@@]1([H])CC[C@H](C)[C@@]([H])(O1)[C@@H](C)C([O-])=O)C[C@@H](OC)[C@H]2C)[C@@]1([H])O[C@@](O)(CO)[C@H](C)C[C@@H]1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Nigericin sodium salt

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 74.69 100

Preparing Stock Solutions for Nigericin sodium salt

The following data is based on the product molecular weight 746.94. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.34 mL 6.69 mL 13.39 mL
5 mM 0.27 mL 1.34 mL 2.68 mL
10 mM 0.13 mL 0.67 mL 1.34 mL
50 mM 0.03 mL 0.13 mL 0.27 mL

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Product Datasheets for Nigericin sodium salt

Certificate of Analysis / Product Datasheet
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References for Nigericin sodium salt

References are publications that support the biological activity of the product.

Hamidinia et al (2004) The ionophore Nigericin transports Pb2+ with high activity and selectivity: A comparison to Monensin and Ionomycin. Biochemistry. 43 15956 PMID: 15595852

Eytan et al (1990) Energy-linked transhydrogenase: Effects of Valinomycin and Nigericin on the ATP-driven transhydrogenase reaction catalyzed by reconstituted transhydrogenase-ATPase vesicles. J.Biol.Chem. 22 12949


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Keywords: Nigericin sodium salt, Nigericin sodium salt supplier, K+, potassium, ionophore, ionophores, exchanges, hydrogen, ions, exchanger, Ionophores, 4312, Tocris Bioscience

8 Citations for Nigericin sodium salt

Citations are publications that use Tocris products. Selected citations for Nigericin sodium salt include:

Platnich et al (2018) Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome. Cell Rep 25 1525 PMID: 30404007

Krzesniak et al (2020) Synergistic activation of p53 by actinomycin D and nutlin-3a is associated with the upregulation of crucial regulators and effectors of innate immunity Cell Signal 69 PMID: 32032660

Ahn et al (2017) Lentinan from shiitake selectively attenuates AIM2 and non-canonical inflammasome activation while inducing pro-inflammatory cytokine production. Sci Rep 7 1314 PMID: 28465544

Ahn et al (2017) Methylene blue inhibits NLRP3, NLRC4, AIM2, and non-canonical inflammasome activation. Sci Rep 7 12409 PMID: 28963531


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Literature in this Area

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