Nigericin sodium salt
Potassium ionophore, exchanges K+ for H+ across biological membranes, in a similar manner to Valinomycin (Cat. No. 3373). Stimulates mitochondral ATPase activity and disrupts membrane potential. Also acts as an ionophore for Pb2+ with no activity with other divalent cations. Antibiotic derived from Streptomyces hygroscopius.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 746.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.34 mL||6.69 mL||13.39 mL|
|5 mM||0.27 mL||1.34 mL||2.68 mL|
|10 mM||0.13 mL||0.67 mL||1.34 mL|
|50 mM||0.03 mL||0.13 mL||0.27 mL|
References are publications that support the biological activity of the product.
Hamidinia et al (2004) The ionophore Nigericin transports Pb2+ with high activity and selectivity: A comparison to Monensin and Ionomycin. Biochemistry. 43 15956 PMID: 15595852
Eytan et al (1990) Energy-linked transhydrogenase: Effects of Valinomycin and Nigericin on the ATP-driven transhydrogenase reaction catalyzed by reconstituted transhydrogenase-ATPase vesicles. J.Biol.Chem. 22 12949
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Keywords: Nigericin sodium salt, Nigericin sodium salt supplier, K+, potassium, ionophore, ionophores, exchanges, hydrogen, ions, exchanger, Ionophores, 4312, Tocris Bioscience
3 Citations for Nigericin sodium salt
Citations are publications that use Tocris products. Selected citations for Nigericin sodium salt include:
Lee et al (2016) Sulforaphane attenuates activation of NLRP3 and NLRC4 inflammasomes but not AIM2 inflammasome Cellular Immunology 306-307 53 PMID: 27423466
Ahn et al (2017) Lentinan from shiitake selectively attenuates AIM2 and non-canonical inflammasome activation while inducing pro-inflammatory cytokine production. Sci Rep 7 1314 PMID: 28465544
Ahn et al (2017) Methylene blue inhibits NLRP3, NLRC4, AIM2, and non-canonical inflammasome activation. Sci Rep 7 12409 PMID: 28963531
Do you know of a great paper that uses Nigericin sodium salt from Tocris? Please let us know.
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Literature in this Area
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