Nigericin sodium salt

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Description: Selective K+ ionophore
Chemical Name: (2R)-2-[(2R,3S,6R)-6-[[(2S,4R,5R,7R,9R,10R)- 2-[(2R,5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-Hydroxy- 6-(hydroxymethyl)-3,5-dimethyl-2-tetrahydropyranyl]-3-methyl- 2-tetrahydrofuranyl]-5-methyl-2-tetrahydrofuranyl]-9-methoxy- 2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl]methyl]-3-methyl- 2-tetrahydropyranyl]propanoic acid sodium salt
Datasheet
Citations (19)
Reviews

Biological Activity for Nigericin sodium salt

Nigericin sodium salt is a potassium ionophore; it exchanges K+ for H+ across biological membranes in a similar manner to Valinomycin (Cat. No. 3373). Nigericin stimulates mitochondrial ATPase activity and disrupts membrane potential. Also acts as an ionophore for Pb2+ with no activity with other divalent cations. Antibiotic derived from Streptomyces hygroscopius.

Technical Data for Nigericin sodium salt

M. Wt 746.94
Formula C40H67NaO11
Storage Store at -20°C
CAS Number 28643-80-3
PubChem ID 16760591
InChI Key MOYOTUKECQMGHE-PDEFJWSRSA-M
Smiles [Na+].[H][C@@]1(C[C@H](C)[C@@]([H])(O1)[C@]1(C)CC[C@@]([H])(O1)[C@]1(C)C[C@@H](C)[C@]2(O1)O[C@]([H])(C[C@@]1([H])CC[C@H](C)[C@@]([H])(O1)[C@@H](C)C([O-])=O)C[C@@H](OC)[C@H]2C)[C@@]1([H])O[C@@](O)(CO)[C@H](C)C[C@@H]1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Nigericin sodium salt

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 74.69 100

Preparing Stock Solutions for Nigericin sodium salt

The following data is based on the product molecular weight 746.94. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.34 mL 6.69 mL 13.39 mL
5 mM 0.27 mL 1.34 mL 2.68 mL
10 mM 0.13 mL 0.67 mL 1.34 mL
50 mM 0.03 mL 0.13 mL 0.27 mL

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Product Datasheets for Nigericin sodium salt

Certificate of Analysis / Product Datasheet
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References for Nigericin sodium salt

References are publications that support the biological activity of the product.

Hamidinia et al (2004) The ionophore Nigericin transports Pb2+ with high activity and selectivity: A comparison to Monensin and Ionomycin. Biochemistry. 43 15956 PMID: 15595852

Eytan et al (1990) Energy-linked transhydrogenase: Effects of Valinomycin and Nigericin on the ATP-driven transhydrogenase reaction catalyzed by reconstituted transhydrogenase-ATPase vesicles. J.Biol.Chem. 22 12949


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Keywords: Nigericin sodium salt, Nigericin sodium salt supplier, K+, potassium, ionophore, ionophores, exchanges, hydrogen, ions, exchanger, Ionophores, 4312, Tocris Bioscience

19 Citations for Nigericin sodium salt

Citations are publications that use Tocris products. Selected citations for Nigericin sodium salt include:

Matthew et al (2021) Selective activation of PFKL suppresses the phagocytic oxidative burst. Cell 184 4480-4494.e15 PMID: 34320407

José A et al (2021) Spatiotemporal Quantification of Cytosolic pH in Arabidopsis Pollen Tubes. Bio Protoc 11 e4084 PMID: 34395723

Jeongho et al (2021) NLRP3 Triggers Attenuate Lipocalin-2 Expression Independent with Inflammasome Activation. Cells 10 PMID: 34359830

Jun et al (2021) Single-cell lactate production rate as a measure of glycolysis in endothelial cells. STAR Protoc 2 100807 PMID: 34527962

Han et al (2017) Nonsaponin fractions of Korean Red Ginseng extracts prime activation of NLRP3 inflammasome. J Ginseng Res 41 513 PMID: 29021698

Ahn et al (2018) Mercury and arsenic attenuate canonical and non-canonical NLRP3 inflammasome activation. Sci Rep 8 13659 PMID: 30209319

Roche et al (2018) Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation. J Cell Biol 217 3560 PMID: 30054450

Lee et al (2016) Sulforaphane attenuates activation of NLRP3 and NLRC4 inflammasomes but not AIM2 inflammasome Cellular Immunology 306-307 53 PMID: 27423466

Didier et al (2022) Cation ATPase (ATP4) Orthologue Replacement in the Malaria Parasite Plasmodium knowlesi Reveals Species-Specific Responses to ATP4-Targeting Drugs. MBio 13 e0117822 PMID: 36190127

Songyan et al (2022) Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins. Commun Biol 5 47 PMID: 35022507

Yuanyuan et al (2023) IRAK-M suppresses the activation of microglial NLRP3 inflammasome and GSDMD-mediated pyroptosis through inhibiting IRAK1 phosphorylation during experimental autoimmune encephalomyelitis. Cell Death Dis 14 103 PMID: 36765034

Bao-Xue et al (2020) Corticosteroids alleviate lipopolysaccharide-induced inflammation and lung injury via inhibiting NLRP3-inflammasome activation. J Cell Mol Med 24 12716-12725 PMID: 32977368

Alison et al (2020) LAP-like non-canonical autophagy and evolution of endocytic vacuoles in pancreatic acinar cells. Autophagy 16 1314-1331 PMID: 31651224

Kun et al (2018) A Membrane Potential- and Calpain-Dependent Reversal of Caspase-1 Inhibition Regulates Canonical NLRP3 Inflammasome. Cell Rep 24 2356-2369.e5 PMID: 30157429

Ahn et al (2017) Lentinan from shiitake selectively attenuates AIM2 and non-canonical inflammasome activation while inducing pro-inflammatory cytokine production. Sci Rep 7 1314 PMID: 28465544

Ahn et al (2017) Methylene blue inhibits NLRP3, NLRC4, AIM2, and non-canonical inflammasome activation. Sci Rep 7 12409 PMID: 28963531

Bockstiegel et al (2023) Pharmacological inhibition of HDAC6 suppresses xNLRP3 inflammasome-mediated IL-1β release. Biochem Pharmacol PMID: 37481141

Krzesniak et al (2020) Synergistic activation of p53 by actinomycin D and nutlin-3a is associated with the upregulation of crucial regulators and effectors of innate immunity Cell Signal 69 PMID: 32032660

Platnich et al (2018) Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome. Cell Rep 25 1525 PMID: 30404007


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