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Submit ReviewNigericin sodium salt
Description: Selective K+ ionophore
Chemical Name: (2R)-2-[(2R,3S,6R)-6-[[(2S,4R,5R,7R,9R,10R)- 2-[(2R,5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-Hydroxy- 6-(hydroxymethyl)-3,5-dimethyl-2-tetrahydropyranyl]-3-methyl- 2-tetrahydrofuranyl]-5-methyl-2-tetrahydrofuranyl]-9-methoxy- 2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl]methyl]-3-methyl- 2-tetrahydropyranyl]propanoic acid sodium salt
Biological Activity for Nigericin sodium salt
Nigericin sodium salt is a potassium ionophore; it exchanges K+ for H+ across biological membranes in a similar manner to Valinomycin (Cat. No. 3373). Nigericin stimulates mitochondrial ATPase activity and disrupts membrane potential. Also acts as an ionophore for Pb2+ with no activity with other divalent cations. Antibiotic derived from Streptomyces hygroscopius.
Technical Data for Nigericin sodium salt
| M. Wt | 746.94 |
| Formula | C40H67NaO11 |
| Storage | Store at -20°C |
| CAS Number | 28643-80-3 |
| PubChem ID | 16760591 |
| InChI Key | MOYOTUKECQMGHE-PDEFJWSRSA-M |
| Smiles | [Na+].[H][C@@]1(C[C@H](C)[C@@]([H])(O1)[C@]1(C)CC[C@@]([H])(O1)[C@]1(C)C[C@@H](C)[C@]2(O1)O[C@]([H])(C[C@@]1([H])CC[C@H](C)[C@@]([H])(O1)[C@@H](C)C([O-])=O)C[C@@H](OC)[C@H]2C)[C@@]1([H])O[C@@](O)(CO)[C@H](C)C[C@@H]1C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Nigericin sodium salt
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 74.69 | 100 |
Preparing Stock Solutions for Nigericin sodium salt
The following data is based on the product molecular weight 746.94. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.34 mL | 6.69 mL | 13.39 mL |
| 5 mM | 0.27 mL | 1.34 mL | 2.68 mL |
| 10 mM | 0.13 mL | 0.67 mL | 1.34 mL |
| 50 mM | 0.03 mL | 0.13 mL | 0.27 mL |
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Product Datasheets for Nigericin sodium salt
References for Nigericin sodium salt
References are publications that support the biological activity of the product.
Hamidinia et al (2004) The ionophore Nigericin transports Pb2+ with high activity and selectivity: A comparison to Monensin and Ionomycin. Biochemistry. 43 15956 PMID: 15595852
Eytan et al (1990) Energy-linked transhydrogenase: Effects of Valinomycin and Nigericin on the ATP-driven transhydrogenase reaction catalyzed by reconstituted transhydrogenase-ATPase vesicles. J.Biol.Chem. 22 12949
If you know of a relevant reference for Nigericin sodium salt, please let us know.
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Keywords: Nigericin sodium salt, Nigericin sodium salt supplier, K+, potassium, ionophore, ionophores, exchanges, hydrogen, ions, exchanger, Ionophores, 4312, Tocris Bioscience
19 Citations for Nigericin sodium salt
Citations are publications that use Tocris products. Selected citations for Nigericin sodium salt include:
Bao-Xue et al (2020) Corticosteroids alleviate lipopolysaccharide-induced inflammation and lung injury via inhibiting NLRP3-inflammasome activation. J Cell Mol Med 24 12716-12725 PMID: 32977368
Alison et al (2020) LAP-like non-canonical autophagy and evolution of endocytic vacuoles in pancreatic acinar cells. Autophagy 16 1314-1331 PMID: 31651224
Ahn et al (2017) Lentinan from shiitake selectively attenuates AIM2 and non-canonical inflammasome activation while inducing pro-inflammatory cytokine production. Sci Rep 7 1314 PMID: 28465544
Ahn et al (2017) Methylene blue inhibits NLRP3, NLRC4, AIM2, and non-canonical inflammasome activation. Sci Rep 7 12409 PMID: 28963531
Platnich et al (2018) Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome. Cell Rep 25 1525 PMID: 30404007
Jeongho et al (2021) NLRP3 Triggers Attenuate Lipocalin-2 Expression Independent with Inflammasome Activation. Cells 10 PMID: 34359830
Jun et al (2021) Single-cell lactate production rate as a measure of glycolysis in endothelial cells. STAR Protoc 2 100807 PMID: 34527962
Matthew et al (2021) Selective activation of PFKL suppresses the phagocytic oxidative burst. Cell 184 4480-4494.e15 PMID: 34320407
José A et al (2021) Spatiotemporal Quantification of Cytosolic pH in Arabidopsis Pollen Tubes. Bio Protoc 11 e4084 PMID: 34395723
Lee et al (2016) Sulforaphane attenuates activation of NLRP3 and NLRC4 inflammasomes but not AIM2 inflammasome Cellular Immunology 306-307 53 PMID: 27423466
Ahn et al (2018) Mercury and arsenic attenuate canonical and non-canonical NLRP3 inflammasome activation. Sci Rep 8 13659 PMID: 30209319
Roche et al (2018) Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation. J Cell Biol 217 3560 PMID: 30054450
Han et al (2017) Nonsaponin fractions of Korean Red Ginseng extracts prime activation of NLRP3 inflammasome. J Ginseng Res 41 513 PMID: 29021698
Kun et al (2018) A Membrane Potential- and Calpain-Dependent Reversal of Caspase-1 Inhibition Regulates Canonical NLRP3 Inflammasome. Cell Rep 24 2356-2369.e5 PMID: 30157429
Didier et al (2022) Cation ATPase (ATP4) Orthologue Replacement in the Malaria Parasite Plasmodium knowlesi Reveals Species-Specific Responses to ATP4-Targeting Drugs. MBio 13 e0117822 PMID: 36190127
Songyan et al (2022) Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins. Commun Biol 5 47 PMID: 35022507
Krzesniak et al (2020) Synergistic activation of p53 by actinomycin D and nutlin-3a is associated with the upregulation of crucial regulators and effectors of innate immunity Cell Signal 69 PMID: 32032660
Yuanyuan et al (2023) IRAK-M suppresses the activation of microglial NLRP3 inflammasome and GSDMD-mediated pyroptosis through inhibiting IRAK1 phosphorylation during experimental autoimmune encephalomyelitis. Cell Death Dis 14 103 PMID: 36765034
Bockstiegel et al (2023) Pharmacological inhibition of HDAC6 suppresses xNLRP3 inflammasome-mediated IL-1β release. Biochem Pharmacol PMID: 37481141
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