Glutamate (Metabotropic) Group I Receptor Antagonists

Cat. No. Product Name / Activity
5229 ABP 688
High affinity human mGlu5 antagonist
2254 ACDPP hydrochloride
Selective mGlu5 antagonist
0904 AIDA
Potent and selective group I mGlu antagonist
0125 DL-AP3
Group I mGlu antagonist; also phosphoserine phosphatase inhibitor
5614 AZD 2066
mGlu5 antagonist; orally bioavailable and brain penetrant
5613 AZD 9272
Potent and selective mGlu5 antagonist; brain penetrant
0329 (S)-3-Carboxy-4-hydroxyphenylglycine
Group I mGlu antagonist; also group II mGlu agonist
0320 (S)-4-Carboxy-3-hydroxyphenylglycine
Group I mGlu antagonist; also group II mGlu agonist
0323 (S)-4-Carboxyphenylglycine
Competitive group I mGlu antagonist; also weak group II agonist
1028 CPCCOEt
Selective non-competitive mGlu1 antagonist
1749 HexylHIBO
Group I mGlu antagonist
2333 JNJ 16259685
Highly potent, mGlu1-selective non-competitive antagonist
1237 LY 367385
Selective mGlu1a antagonist
2390 LY 456236 hydrochloride
Selective mGlu1 antagonist
2196 3-MATIDA
Potent and selective mGlu1 antagonist
1212 MPEP hydrochloride
Potent mGlu5 antagonist; also positive allosteric modulator of mGlu4 receptors
2921 MTEP hydrochloride
Potent and selective mGlu5 antagonist
4134 NPS 2390
Group I mGlu antagonist
1027 PHCCC
Potent group I mGlu antagonist
1215 SIB 1757
Highly selective mGlu5 antagonist
1214 SIB 1893
mGlu5 antagonist; also positive allosteric modulator at mGlu4 receptors
3413 YM 202074 sesquifumarate
High affinity, selective mGlu1 antagonist
2986 YM 230888
Selective mGlu1 antagonist
2448 YM 298198 hydrochloride
Highly potent, selective non-competitive mGlu1 antagonist
2447 Desmethyl-YM 298198
Derivative of mGlu1 antagonist YM 298198 (Cat. No. 2448)