Glutamate (Metabotropic) Group I Receptor Antagonists

Cat No Product Name / Activity
5229 ABP 688
High affinity human mGlu5 receptor antagonist
2254 ACDPP hydrochloride
Selective mGlu5 receptor antagonist
0904 AIDA
Potent, selective group I mGlu antagonist
0125 DL-AP3
Group I mGlu antagonist
5614 AZD 2066
mGlu5 antagonist; orally bioavailable and brain penetrant
5613 AZD 9272
Potent and selective mGlu5 antagonist; brain penetrant
2501 Bay 36-7620
Non-competitive mGlu1 antagonist with inverse agonist activity
0329 (S)-3-Carboxy-4-hydroxyphenylglycine
Group I antagonist/group II agonist
0320 (S)-4-Carboxy-3-hydroxyphenylglycine
Group I antagonist/group II agonist
0323 (S)-4-Carboxyphenylglycine
Competitive group I mGlu antagonist/weak group II agonist
1028 CPCCOEt
Selective non-competitive mGlu1 receptor antagonist
1009 E4CPG
Group I/group II mGlu antagonist
2386 Fenobam
Potent and selective mGlu5 antagonist
1749 HexylHIBO
Group I mGlu antagonist
1750 (S)-HexylHIBO
Group I mGlu antagonist
2333 JNJ 16259685
Highly potent, mGlu1-selective non-competitive antagonist
1237 LY 367385
Selective mGlu1a antagonist
2390 LY 456236 hydrochloride
Selective mGlu1 antagonist
2196 3-MATIDA
Potent, selective mGlu1 antagonist
0336 (RS)-MCPG
Non-selective mGlu antagonist
3696 (RS)-MCPG disodium salt
Sodium salt of (RS)-MCPG (Cat. No. 0336)
0337 (S)-MCPG
Non-selective mGlu antagonist. Active isomer of Cat. No. 0336
1212 MPEP hydrochloride
mGlu5 antagonist and positive allosteric modulator at mGlu4
2921 MTEP hydrochloride
Potent, selective mGlu5 antagonist
4134 NPS 2390
Group I mGlu antagonist
1027 PHCCC
Potent group I mGlu antagonist
1215 SIB 1757
Highly selective mGlu5 antagonist
1214 SIB 1893
mGlu5 antagonist and positive allosteric modulator at mGlu4
3413 YM 202074
High affinity, selective mGlu1 antagonist
2986 YM 230888
Selective mGlu1 antagonist
2448 YM 298198 hydrochloride
Highly potent, selective non-competitive mGlu1 antagonist
2447 Desmethyl-YM 298198
Derivative of mGlu1 antagonist YM 298198 (Cat. No. 2448)