Glutamate (Metabotropic) Group I Receptor Antagonists

Cat. No. Product Name / Activity
5229 ABP 688
High affinity human mGlu5 antagonist
0904 AIDA
Potent and selective group I mGlu antagonist
5614 AZD 2066
mGlu5 antagonist; orally bioavailable and brain penetrant
5613 AZD 9272
Potent and selective mGlu5 antagonist; brain penetrant
0323 (S)-4-Carboxyphenylglycine
Competitive group I mGlu antagonist; also weak group II agonist
1028 CPCCOEt
Selective non-competitive mGlu1 antagonist
2333 JNJ 16259685
Highly potent, mGlu1-selective non-competitive antagonist
1237 LY 367385
Selective mGlu1a antagonist
2390 LY 456236 hydrochloride
Selective mGlu1 antagonist
1212 MPEP hydrochloride
Potent mGlu5 antagonist; also positive allosteric modulator of mGlu4 receptors
2921 MTEP hydrochloride
Potent and selective mGlu5 antagonist
4134 NPS 2390
Group I mGlu antagonist
1027 PHCCC
Potent group I mGlu antagonist