AZD 2066

Pricing Availability   Qty
Description: mGlu5 antagonist; orally bioavailable and brain penetrant
Chemical Name: 4-[5-[(1R)-1-[5-(3-Chlorophenyl)-3-isoxazolyl]ethoxy]-4-methyl-4H-1,2,4-triazol-3-yl]pyridine
Purity: ≥98% (HPLC)
Literature (5)

Biological Activity for AZD 2066

AZD 2066 is an mGlu5 antagonist. Displays discriminative effects in rats. Orally bioavailable and brain penetrant.

Compound Libraries for AZD 2066

AZD 2066 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AZD 2066

M. Wt 381.82
Formula C19H16ClN5O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 934282-55-0
PubChem ID 16041426
Smiles CN1C(C2=CC=NC=C2)=NN=C1O[C@H](C)C3=NOC(C4=CC=CC(Cl)=C4)=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AZD 2066

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 38.18 100
ethanol 38.18 100

Preparing Stock Solutions for AZD 2066

The following data is based on the product molecular weight 381.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.62 mL 13.1 mL 26.19 mL
5 mM 0.52 mL 2.62 mL 5.24 mL
10 mM 0.26 mL 1.31 mL 2.62 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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References for AZD 2066

References are publications that support the biological activity of the product.

Swedberg et al (2014) AZD9272 and AZD2066: selective and highly central nervous system penetrant mGluR5 antagonists characterized by their discriminative effects. J.Pharmacol.Exp.Ther. 350 212 PMID: 24876235

If you know of a relevant reference for AZD 2066, please let us know.

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Citations for AZD 2066

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Metabotropic Glutamate Receptors Scientific Review

Metabotropic Glutamate Receptors Scientific Review

Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.

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