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Description: Potent and selective group I mGlu antagonist
Alternative Names: UPF 523
Chemical Name: (RS)-1-Aminoindan-1,5-dicarboxylic acid
Purity: ≥98% (HPLC)
Biological Activity for AIDA
AIDA is a relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu1a), having no effect on group II (mGlu2) or group III (mGlu4) receptors expressed individually in baby hamster kidney cells. Has no effect on ionotropic glutamate receptors. Centrally active following systemic administration in vivo.
Technical Data for AIDA
| M. Wt | 221.21 |
| Formula | C11H11NO4 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 168560-79-0 |
| PubChem ID | 2071 |
| InChI Key | LSTPKMWNRWCNLS-UHFFFAOYSA-N |
| Smiles | NC2(C(O)=O)C1=CC=C(C(O)=O)C=C1CC2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AIDA
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1.1eq. NaOH | 22.12 | 100 |
Preparing Stock Solutions for AIDA
The following data is based on the product molecular weight 221.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.52 mL | 22.6 mL | 45.21 mL |
| 5 mM | 0.9 mL | 4.52 mL | 9.04 mL |
| 10 mM | 0.45 mL | 2.26 mL | 4.52 mL |
| 50 mM | 0.09 mL | 0.45 mL | 0.9 mL |
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Product Datasheets for AIDA
References for AIDA
References are publications that support the biological activity of the product.
Moroni et al (1997) Pharmacological characterization of 1-aminoindan-1,5-dicarboxylic acid, a potent mGluR1 antagonist. J.Pharmacol.Exp.Ther. 281 721 PMID: 9152378
Nielsen et al (1997) Class I mGlu receptor antagonist 1-aminoindan-1,5-dicarboxylic acid blocks contextual but not cue conditioning in rats. Eur.J.Pharmacol. 326 105 PMID: 9196260
Pellicciari et al (1995) 1-Aminoindan-1,5-dicarboxylic acid: a novel antagonist at phospholipase C-linked metabotropic glutamate receptors. J.Med.Chem. 38 3717 PMID: 7562903
If you know of a relevant reference for AIDA, please let us know.
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Keywords: AIDA, AIDA supplier, Potent, selective, group, I, antagonist, Group, Receptors, mGlu1, mGlu5, mGluR1, mGluR5, Glutamate, Metabotropic, UPF523, UPF, 523, (Metabotropic), 0904, Tocris Bioscience
9 Citations for AIDA
Citations are publications that use Tocris products. Selected citations for AIDA include:
Wibrand et al (2010) Differential regulation of mature and precursor microRNA expression by NMDA and metabotropic glutamate receptor activation during LTP in the adult dentate gyrus in vivo. Eur J Neurosci 31 636 PMID: 20384810
Pan et al (2004) Effects of the group I metabotropic glutamate receptor agonist, DHPG, and injection stress on striatal cell signaling in food-restricted and ad libitum fed rats. BMC Neurosci 5 50 PMID: 15579204
Ady et al (2014) Type 1 metabotropic glutamate receptors (mGlu1) trigger the gating of GluD2 δ glutamate receptors. J Neurosci 15 103 PMID: 24357660
Mahler et al (2014) Modafinil attenuates reinstatement of cocaine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors. Proc Natl Acad Sci U S A 19 49 PMID: 23017017
De-May and Ali (2013) Cell type-specific regulation of inhibition via cannabinoid type 1 receptors in rat neocortex. J Neurophysiol 109 216 PMID: 23054605
Yeckel et al (1999) Multiple forms of LTP in hippocampal CA3 neurons use a common postsynaptic mechanism. Nat Neurosci 2 625 PMID: 10404192
Shin et al (2008) Dendritic glutamate release produces autocrine activation of mGluR1 in cerebellar Purkinje cells. EMBO Rep 105 746 PMID: 18174329
Saitoh et al (2016) Glutamate signals through mGluR2 to control Schwann cell differentiation and proliferation Scientific Reports 6 29856 PMID: 27432639
Cassé et al (2012) Glutamate controls tPA recycling by astrocytes, which in turn influences glutamatergic signals. J Neurosci 32 5186 PMID: 22496564
Do you know of a great paper that uses AIDA from Tocris? Please let us know.
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