AIDA

Pricing Availability   Qty
Description: Potent and selective group I mGlu antagonist
Alternative Names: UPF 523
Chemical Name: (RS)-1-Aminoindan-1,5-dicarboxylic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (9)
Reviews
Literature (10)

Biological Activity for AIDA

AIDA is a relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu1a), having no effect on group II (mGlu2) or group III (mGlu4) receptors expressed individually in baby hamster kidney cells. Has no effect on ionotropic glutamate receptors. Centrally active following systemic administration in vivo.

Technical Data for AIDA

M. Wt 221.21
Formula C11H11NO4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 168560-79-0
PubChem ID 2071
InChI Key LSTPKMWNRWCNLS-UHFFFAOYSA-N
Smiles NC2(C(O)=O)C1=CC=C(C(O)=O)C=C1CC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AIDA

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1.1eq. NaOH 22.12 100

Preparing Stock Solutions for AIDA

The following data is based on the product molecular weight 221.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.52 mL 22.6 mL 45.21 mL
5 mM 0.9 mL 4.52 mL 9.04 mL
10 mM 0.45 mL 2.26 mL 4.52 mL
50 mM 0.09 mL 0.45 mL 0.9 mL

Molarity Calculator

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Product Datasheets for AIDA

Certificate of Analysis / Product Datasheet
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References for AIDA

References are publications that support the biological activity of the product.

Moroni et al (1997) Pharmacological characterization of 1-aminoindan-1,5-dicarboxylic acid, a potent mGluR1 antagonist. J.Pharmacol.Exp.Ther. 281 721 PMID: 9152378

Nielsen et al (1997) Class I mGlu receptor antagonist 1-aminoindan-1,5-dicarboxylic acid blocks contextual but not cue conditioning in rats. Eur.J.Pharmacol. 326 105 PMID: 9196260

Pellicciari et al (1995) 1-Aminoindan-1,5-dicarboxylic acid: a novel antagonist at phospholipase C-linked metabotropic glutamate receptors. J.Med.Chem. 38 3717 PMID: 7562903


If you know of a relevant reference for AIDA, please let us know.

View Related Products by Product Action

View all Glutamate (Metabotropic) Group I Receptor Antagonists

Keywords: AIDA, AIDA supplier, Potent, selective, group, I, antagonist, Group, Receptors, mGlu1, mGlu5, mGluR1, mGluR5, Glutamate, Metabotropic, UPF523, UPF, 523, (Metabotropic), 0904, Tocris Bioscience

9 Citations for AIDA

Citations are publications that use Tocris products. Selected citations for AIDA include:

Wibrand et al (2010) Differential regulation of mature and precursor microRNA expression by NMDA and metabotropic glutamate receptor activation during LTP in the adult dentate gyrus in vivo. Eur J Neurosci 31 636 PMID: 20384810

Pan et al (2004) Effects of the group I metabotropic glutamate receptor agonist, DHPG, and injection stress on striatal cell signaling in food-restricted and ad libitum fed rats. BMC Neurosci 5 50 PMID: 15579204

Ady et al (2014) Type 1 metabotropic glutamate receptors (mGlu1) trigger the gating of GluD2 δ glutamate receptors. J Neurosci 15 103 PMID: 24357660

Mahler et al (2014) Modafinil attenuates reinstatement of cocaine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors. Proc Natl Acad Sci U S A 19 49 PMID: 23017017


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Reviews for AIDA

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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