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Group I mGlu antagonist; displays noncompetitive antagonist activity at both mGlu1 and mGlu5 receptors. Thought to act on a site separate from the glutamate binding pocket.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 307.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||6.51 mL||32.53 mL||65.06 mL|
|2.5 mM||1.3 mL||6.51 mL||13.01 mL|
|5 mM||0.65 mL||3.25 mL||6.51 mL|
|25 mM||0.13 mL||0.65 mL||1.3 mL|
References are publications that support the biological activity of the product.
Lavreysen et al (2003) [3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists. Mol.Pharmacol. 63 1082 PMID: 12695537
Mabire et al (2005) Synthesis, structure-activity relationship, and receptor pharmacology of a new series of quinoline derivatives acting as selective, noncompetitive mGlu1 antagonists. J.Med.Chem. 48 2134 PMID: 15771457
van Wagenen et al (2000) Structure-activity relationship studies of NPS 2390: a potent and selective group I metabotropic glutamate receptor antagonist. Abstr.Soc.Neurosci. Program No. 618.3.
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Keywords: NPS 2390, NPS 2390 supplier, NPS2390, type, I, metabotropic, glutamate, mglu, mglur1, mglur5, antagonists, Glutamate, (Metabotropic), Group, Receptors, 4134, Tocris Bioscience
1 Citation for NPS 2390
Citations are publications that use Tocris products. Selected citations for NPS 2390 include:
Li et al (2016) Calcium Oxalate Induces Renal Injury through Calcium-Sensing Receptor. Oxid Med Cell Longev 2016 5203801 PMID: 27965733
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Reviews for NPS 2390
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NPS 2390 was used as a specific blocker of mGluR1 and mGluR5, to isolate pharmacologically response of GABA-A receptors. 10 microM of NPS 2390 in perfusion solution generated a full block of mGluR group I receptor activity, thus leaving a clear GABA-ergic response. Figure: single-channel openings of GABA-A receptor after application of NPS 2390.
Compound requires sonication to be dissolved.
Literature in this Area
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