LY 456236 hydrochloride

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Cat.No. 2390 - LY 456236 hydrochloride | C16H15N3O2.HCl | CAS No. 338736-46-2
Description: Selective mGlu1 antagonist
Alternative Names: MPMQ hydrochloride
Chemical Name: 6-Methoxy-N-(4-methoxyphenyl)-4-quinazolinamine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective mGlu1 receptor antagonist (IC50 values are 143 nM and > 10 μM for mGlu1 and mGlu5 receptors respectively). Reduces hyperalgesic behavior induced by formalin in both mouse and rat with ED50 values of 28 and 16.3 mg/kg respectively.

Compound Libraries

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Technical Data

M. Wt 317.77
Formula C16H15N3O2.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 338736-46-2
PubChem ID 9926998
InChI Key AVKFOWUSTVWZQN-UHFFFAOYSA-N
Smiles Cl.COC1=CC=C(NC2=C3C=C(OC)C=CC3=NC=N2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 6.36 20

Preparing Stock Solutions

The following data is based on the product molecular weight 317.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.15 mL 15.73 mL 31.47 mL
5 mM 0.63 mL 3.15 mL 6.29 mL
10 mM 0.31 mL 1.57 mL 3.15 mL
50 mM 0.06 mL 0.31 mL 0.63 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Shannon et al (2005) Anticonvulsant effects of LY456236, a selective mGlu1 receptor antagonist. Neuropharmacology 49 188 PMID: 16011839

Bertorelli et al (2005) Selective blockade of metabotropic glutamate subtype mGluR1 receptors induce anti-nociceptive effects. Neuropharmacology 49 231 PMID:


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Citations for LY 456236 hydrochloride

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