FAK Inhibitor 14

Pricing Availability Delivery Time Qty
Cat.No. 3414 - FAK Inhibitor 14 | C6H10N4.4HCl | CAS No. 4506-66-5
Description: Selective FAK inhibitor
Alternative Names: Y15, NSC 677249
Chemical Name: 1,2,4,5-Benzenetetramine tetrahydrochloride
Citations (11)

Biological Activity

Selective focal adhesion kinase (FAK) inhibitor that displays no significant activity at a range of other kinases including EGFR, PDGFR and IGF-RI. Prevents FAK autophosphorylation at Y397 (IC50 = 1 μM), promotes cell detachment and inhibits cell adhesion in vitro. Exhibits antiproliferative activity in a variety of human tumor cell lines in vitro and in breast cancer cells in vivo.

Technical Data

M. Wt 284.01
Formula C6H10N4.4HCl
Storage Desiccate at RT
CAS Number 4506-66-5
PubChem ID 78260
Smiles NC1=C(N)C=C(N)C(N)=C1.Cl.Cl.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 21.3 75
water 14.2 50

Preparing Stock Solutions

The following data is based on the product molecular weight 284.01. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.52 mL 17.61 mL 35.21 mL
5 mM 0.7 mL 3.52 mL 7.04 mL
10 mM 0.35 mL 1.76 mL 3.52 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet


References are publications that support the products' biological activity.

Golubovskaya et al (2008) A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the Y397 site of focal adhesion kinase decreases tumour growth. J.Med.Chem. 51 7405 PMID: 18989950

Hochwald et al (2009) A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer. Cell Cycle 8 2435 PMID: 19571674

If you know of a relevant reference for FAK Inhibitor 14, please let us know.

View Related Products by Product Action

View all Focal Adhesion Kinase Inhibitors

Keywords: FAK Inhibitor 14, supplier, Selective, FAK, inhibitors, inhibits, Focal, Adhesion, Kinases, Inhibitor14, Y15, NSC, 677249, Focal, Adhesion, Kinase, Focal, Adhesion, Kinase, Tocris Bioscience

11 Citations for FAK Inhibitor 14

Citations are publications that use Tocris products. Selected citations for FAK Inhibitor 14 include:

Rengarajan et al (2016) Endothelial Cells Use a Formin-Dependent Phagocytosis-Like Process to Internalize the Bacterium Listeria monocytogenes. PLoS One 12 e1005603 PMID: 27152864

Visavadiya (2016) Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3. Cell Communication and Signaling 14 32 PMID: 27978828

Tu et al (2010) GABAB receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation. J Neurosci 30 749 PMID: 20071540

Webber et al (2015) Combination of heat shock protein 90 and focal adhesion kinase inhibitors synergistically inhibits the growth of non-small cell lung cancer cells. Oncoscience 2 765 PMID: 26501082

Gutiérrez et al (2015) RECK-Mediated β1-Integrin Regulation by TGF-β1 Is Critical for Wound Contraction in Mice. J Neurosci 10 e0135005 PMID: 26247610

Shih et al (2014) Astroglial-derived periostin promotes axonal regeneration after spinal cord injury. Auton Neurosci 34 2438 PMID: 24523534

Mendoza-Naranjo et al (2013) ERBB4 confers metastatic capacity in Ewing sarcoma. EMBO Mol Med 5 1019 PMID: 23681745

Malenczyk et al (2013) CB1 cannabinoid receptors couple to focal adhesion kinase to control insulin release. J Biol Chem 288 32685 PMID: 24089517

Keasey et al (2013) Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression. Cell Commun Signal 11 35 PMID: 23693126

Wiel et al (2013) Lysyl oxidase activity regulates oncogenic stress response and tumorigenesis. Cell Death Dis 4 e855 PMID: 24113189

Afrikanova et al (2011) Inhibitors of Src and focal adhesion kinase promote endocrine specification: impact on the derivation of β-cells from human pluripotent stem cells. J Biol Chem 286 36042 PMID: 21852242

Do you know of a great paper that uses FAK Inhibitor 14 from Tocris? If so please let us know.

Reviews for FAK Inhibitor 14

There are currently no reviews for this product. Be the first to review FAK Inhibitor 14 and earn rewards!

Have you used FAK Inhibitor 14?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases