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Biological Activity for GSK 2256098
GSK 2256098 is a potent, reversible and ATP-competitive focal adhesion kinase (FAK) inhibitor (IC50 values are 8.5 nM, 12 nM and 15 nM in U87MG, A549 and OVCAR8 cell lines respectively). Inhibits Y397 phosphorylation and motility, growth and survival of pancreatic ductal adenocarcinoma cells.
Technical Data for GSK 2256098
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for GSK 2256098
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for GSK 2256098
The following data is based on the product molecular weight 414.89. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.41 mL||12.05 mL||24.1 mL|
|5 mM||0.48 mL||2.41 mL||4.82 mL|
|10 mM||0.24 mL||1.21 mL||2.41 mL|
|50 mM||0.05 mL||0.24 mL||0.48 mL|
References for GSK 2256098
References are publications that support the biological activity of the product.
Zhang et al (2014) A small molecule FAK kinase inhibitor, GSK2256098, inhibits growth and survival of pancreatic ductal adenocarcinoma cells. Cell Cycle 13 3143 PMID: 25486573
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Keywords: GSK 2256098, GSK 2256098 supplier, GSK2256098, focal, adhesion, kinase, FAK, inhibitors, inhibition, inhibit, inhibits, PTK2, protein, tyrosine, Y397, phorphorylation, PDAC, pancreatic, ductal, adenocarcinoma, Focal, Adhesion, Kinase, 7786, Tocris Bioscience
Citations for GSK 2256098
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Literature in this Area
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