GSK 2256098

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Description: Potent focal adhesion kinase (FAK) inhibitor
Chemical Name: 2-[[5-Chloro-2-[[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino]-4-pyridinyl]amino]-N-methoxybenzamide
Purity: ≥98% (HPLC)

Biological Activity for GSK 2256098

GSK 2256098 is a potent, reversible and ATP-competitive focal adhesion kinase (FAK) inhibitor (IC50 values are 8.5 nM, 12 nM and 15 nM in U87MG, A549 and OVCAR8 cell lines respectively). Inhibits Y397 phosphorylation and motility, growth and survival of pancreatic ductal adenocarcinoma cells.

Technical Data for GSK 2256098

M. Wt 414.89
Formula C20H23ClN6O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1224887-10-8
PubChem ID 46214930
Smiles O=C(C1=C(NC2=CC(NC3=CC(C)=NN3C(C)C)=NC=C2Cl)C=CC=C1)NOC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for GSK 2256098

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 41.49 100
ethanol 20.74 50

Preparing Stock Solutions for GSK 2256098

The following data is based on the product molecular weight 414.89. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.41 mL 12.05 mL 24.1 mL
5 mM 0.48 mL 2.41 mL 4.82 mL
10 mM 0.24 mL 1.21 mL 2.41 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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References for GSK 2256098

References are publications that support the biological activity of the product.

Zhang et al (2014) A small molecule FAK kinase inhibitor, GSK2256098, inhibits growth and survival of pancreatic ductal adenocarcinoma cells. Cell Cycle 13 3143 PMID: 25486573

If you know of a relevant reference for GSK 2256098, please let us know.

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Citations for GSK 2256098

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