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FLT3

FMS-like receptor tyrosine kinase-3 (FLT3) is a member of the class III RTK (receptor tyrosine kinase) family and is expressed primarily in hematopoietic progenitor cells. Its expression in these cells means that FLT3 has an important role in the pathogenesis of AML.

Products
Background
Literature (1)
Gene Data

FLT3 Inhibitors
Cat. No. Product Name / Activity
5013 AC 710
Potent FLT3 inhibitor; also inhibits other PDGFR family members
6905 Ceritinib
Potent FLT3 inhibitor; also potently inhibits ALK, IR, IGF1R and STK22D
5260 KG 5
PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor; antiangiogenic
3395 Lestaurtinib
FLT3, JAK2 and TrkA inhibitor; also inhibits AurA and AurB
6788 Quizartinib
Highly potent FLT3 inhibitor
6814 Sorafenib
Flt-3 inhibitor; also inhibits Raf-1, VEGFR-2, VEGFR-3, PDGFR-β and cKIT
3037 SU 5416
Inhbitor of VEGFR, KIT, RET, MET and FLT3
2591 TCS 359
Potent FLT3 inhibitor
5422 XL 184
Potent FLT3 inhibitor; also inhibits other RTKs

FMS-like receptor tyrosine kinase-3 (FLT3) is a member of the class III RTK (receptor tyrosine kinase) family and is expressed primarily in hematopoietic progenitor cells. The expression within these cells demonstrates that FLT3 has an important role in the pathogenesis of AML (acute myelogenous leukemia), under which conditions wild type receptors are overexpressed or mutated forms of the receptor are present. Inhibitors of both mutated and wild type receptors are therefore of interest in a therapeutic context.

External sources of pharmacological information for FLT3 :

    Literature for FLT3

    Tocris offers the following scientific literature for FLT3 to showcase our products. We invite you to request* your copy today!

    *Please note that Tocris will only send literature to established scientific business / institute addresses.

    Cancer Research Product Guide

    Cancer Research Product Guide

    A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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    FLT3 Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    FLT3 Human FLT3 NM_004119 P36888
    Mouse Flt3 NM_010229 Q00342
    Rat Flt3 NM_001100822 Q8K553