FLT3

FMS-like receptor tyrosine kinase-3 (FLT3) is a member of the class III RTK (receptor tyrosine kinase) family and is expressed primarily in hematopoietic progenitor cells. Its expression in these cells means that FLT3 has an important role in the pathogenesis of AML.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
5013 AC 710
Potent FLT3 inhibitor; also inhibits other PDGFR family members
5800 CHMFL-FLT3-122
Potent and selective FLT3 inhibitor
4033 5'-Fluoroindirubinoxime
FLT3 inhibitor; displays antiproliferative activity
6056 GSK 1363089
Potent FLT3 inhibtor; also inhibits of MET, VEGFR2, Ron and AXL
5260 KG 5
PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor; antiangiogenic
3395 Lestaurtinib
FLT3, JAK2 and TrkA inhibitor; also inhibits AurA and AurB
3037 SU 5416
Inhbitor of VEGFR, KIT, RET, MET and FLT3
2591 TCS 359
Potent FLT3 inhibitor
5422 XL 184
Potent FLT3 inhibitor; also inhibits other RTKs

FMS-like receptor tyrosine kinase-3 (FLT3) is a member of the class III RTK (receptor tyrosine kinase) family and is expressed primarily in hematopoietic progenitor cells. The expression within these cells demonstrates that FLT3 has an important role in the pathogenesis of AML (acute myelogenous leukemia), under which conditions wild type receptors are overexpressed or mutated forms of the receptor are present. Inhibitors of both mutated and wild type receptors are therefore of interest in a therapeutic context.

Literature for FLT3

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

FLT3 Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
FLT3 Human FLT3 NM_004119 P36888
Mouse Flt3 NM_010229 Q00342
Rat Flt3 NM_001100822 Q8K553