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Potent inhibitor of FLT3 receptor tyrosine kinase (IC50 = 42 nM) that displays selectivity over a range of other kinases. Exhibits antiproliferative effects on MV4-11 cells, a human acute myelogenous leukemia cell line expressing a constitutively active mutant FLT3 (IC50 = 340 nM).
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 360.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.3 mM||9.25 mL||46.24 mL||92.48 mL|
|1.5 mM||1.85 mL||9.25 mL||18.5 mL|
|3 mM||0.92 mL||4.62 mL||9.25 mL|
|15 mM||0.18 mL||0.92 mL||1.85 mL|
References are publications that support the biological activity of the product.
Patch et al (2006) Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3. Bioorg.Med.Chem.Lett. 16 3282 PMID: 16580199
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Keywords: TCS 359, TCS 359 supplier, Potent, FLT3, inhibitors, inhibits, RTKs, Receptor, Tyrosine, Kinases, TCS359, 2591, Tocris Bioscience
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