TCS 359

Pricing Availability   Qty
Description: Potent FLT3 inhibitor
Chemical Name: 2-[(3,4-Dimethoxybenzoyl)amino]-4,5,6,7-benzo[b]thiophene-3-carboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for TCS 359

TCS 359 is a potent inhibitor of FLT3 receptor tyrosine kinase (IC50 = 42 nM) that displays selectivity over a range of other kinases. Exhibits antiproliferative effects on MV4-11 cells, a human acute myelogenous leukemia cell line expressing a constitutively active mutant FLT3 (IC50 = 340 nM).

Technical Data for TCS 359

M. Wt 360.43
Formula C18H20N2O4S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 301305-73-7
PubChem ID 1048845
InChI Key FSPQCTGGIANIJZ-UHFFFAOYSA-N
Smiles COC1=CC=C(C=C1OC)C(=O)NC1=C(C(N)=O)C2=C(CCCC2)S1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TCS 359

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.81 30

Preparing Stock Solutions for TCS 359

The following data is based on the product molecular weight 360.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.3 mM 9.25 mL 46.24 mL 92.48 mL
1.5 mM 1.85 mL 9.25 mL 18.5 mL
3 mM 0.92 mL 4.62 mL 9.25 mL
15 mM 0.18 mL 0.92 mL 1.85 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for TCS 359

References are publications that support the biological activity of the product.

Patch et al (2006) Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3. Bioorg.Med.Chem.Lett. 16 3282 PMID: 16580199


If you know of a relevant reference for TCS 359, please let us know.

View Related Products by Target

View Related Products by Product Action

View all FLT3 Inhibitors

Keywords: TCS 359, TCS 359 supplier, Potent, FLT3, inhibitors, inhibits, RTKs, Receptor, Tyrosine, Kinases, TCS359, 2591, Tocris Bioscience

Citations for TCS 359

Citations are publications that use Tocris products.

Currently there are no citations for TCS 359. Do you know of a great paper that uses TCS 359 from Tocris? Please let us know.

Reviews for TCS 359

There are currently no reviews for this product. Be the first to review TCS 359 and earn rewards!

Have you used TCS 359?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review