Potent inhibitor of FLT3 receptor tyrosine kinase (IC50 = 42 nM) that displays selectivity over a range of other kinases. Exhibits antiproliferative effects on MV4-11 cells, a human acute myelogenous leukemia cell line expressing a constitutively active mutant FLT3 (IC50 = 340 nM).
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 360.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.3 mM||9.25 mL||46.24 mL||92.48 mL|
|1.5 mM||1.85 mL||9.25 mL||18.5 mL|
|3 mM||0.92 mL||4.62 mL||9.25 mL|
|15 mM||0.18 mL||0.92 mL||1.85 mL|
References are publications that support the biological activity of the product.
Patch et al (2006) Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3. Bioorg.Med.Chem.Lett. 16 3282 PMID: 16580199
If you know of a relevant reference for TCS 359, please let us know.
View Related Products by Product Action
Keywords: TCS 359, TCS 359 supplier, Potent, FLT3, inhibitors, inhibits, RTKs, Receptor, Tyrosine, Kinases, TCS359, 2591, Tocris Bioscience
Citations for TCS 359
Citations are publications that use Tocris products.
Currently there are no citations for TCS 359. Do you know of a great paper that uses TCS 359 from Tocris? Please let us know.
Reviews for TCS 359
There are currently no reviews for this product. Be the first to review TCS 359 and earn rewards!
Have you used TCS 359?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.