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Biological Activity for TCS 359
TCS 359 is a potent inhibitor of FLT3 receptor tyrosine kinase (IC50 = 42 nM) that displays selectivity over a range of other kinases. Exhibits antiproliferative effects on MV4-11 cells, a human acute myelogenous leukemia cell line expressing a constitutively active mutant FLT3 (IC50 = 340 nM).
Technical Data for TCS 359
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TCS 359
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for TCS 359
The following data is based on the product molecular weight 360.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.3 mM||9.25 mL||46.24 mL||92.48 mL|
|1.5 mM||1.85 mL||9.25 mL||18.5 mL|
|3 mM||0.92 mL||4.62 mL||9.25 mL|
|15 mM||0.18 mL||0.92 mL||1.85 mL|
References for TCS 359
References are publications that support the biological activity of the product.
Patch et al (2006) Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3. Bioorg.Med.Chem.Lett. 16 3282 PMID: 16580199
If you know of a relevant reference for TCS 359, please let us know.
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Keywords: TCS 359, TCS 359 supplier, Potent, FLT3, inhibitors, inhibits, RTKs, Receptor, Tyrosine, Kinases, TCS359, 2591, Tocris Bioscience
Citations for TCS 359
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Literature in this Area
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