TCS 359

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Cat.No. 2591 - TCS 359 | C18H20N2O4S | CAS No. 301305-73-7
Description: Potent FLT3 inhibitor
Chemical Name: 2-[(3,4-Dimethoxybenzoyl)amino]-4,5,6,7-benzo[b]thiophene-3-carboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent inhibitor of FLT3 receptor tyrosine kinase (IC50 = 42 nM) that displays selectivity over a range of other kinases. Exhibits antiproliferative effects on MV4-11 cells, a human acute myelogenous leukemia cell line expressing a constitutively active mutant FLT3 (IC50 = 340 nM).

Compound Libraries

TCS 359 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox I. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 360.43
Formula C18H20N2O4S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 301305-73-7
PubChem ID 1048845
InChI Key FSPQCTGGIANIJZ-UHFFFAOYSA-N
Smiles COC1=CC=C(C=C1OC)C(=O)NC1=C(C(N)=O)C2=C(CCCC2)S1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.81 30

Preparing Stock Solutions

The following data is based on the product molecular weight 360.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.3 mM 9.25 mL 46.24 mL 92.48 mL
1.5 mM 1.85 mL 9.25 mL 18.5 mL
3 mM 0.92 mL 4.62 mL 9.25 mL
15 mM 0.18 mL 0.92 mL 1.85 mL

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References

References are publications that support the biological activity of the product.

Patch et al (2006) Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3. Bioorg.Med.Chem.Lett. 16 3282 PMID: 16580199


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