Quizartinib

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Description: Highly potent FLT3 inhibitor
Chemical Name: N-[5-(1,1-Dimethylethyl)-3-isoxazolyl]-N'-[4-[7-[2-(4-morpholinyl)ethoxy]imidazo[2,1-b]benzothiazol-2-yl]phenyl]urea
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews

Biological Activity for Quizartinib

Quizartinib is a highly potent FMS-like receptor tyrosine kinase-3 (FLT3) inhibitor (Kd = 1.6 nM, IC50 = 0.56 nM in MV4-11 cell proliferation assay). Displays >10-fold selectivity for FLT3 over panel of 400 kinases. Inhibits FLT3 activity and displays antitumor properties in a mouse MV4-11 tumor xenograft model.

Compound Libraries for Quizartinib

Quizartinib is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for Quizartinib

M. Wt 560.67
Formula C29H32N6O4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 950769-58-1
PubChem ID 24889392
InChI Key CVWXJKQAOSCOAB-UHFFFAOYSA-N
Smiles CC(C)(C1=CC(NC(NC2=CC=C(C3=CN4C(SC5=CC(OCCN6CCOCC6)=CC=C45)=N3)C=C2)=O)=NO1)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Quizartinib

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 56.07 100

Preparing Stock Solutions for Quizartinib

The following data is based on the product molecular weight 560.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.78 mL 8.92 mL 17.84 mL
5 mM 0.36 mL 1.78 mL 3.57 mL
10 mM 0.18 mL 0.89 mL 1.78 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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References for Quizartinib

References are publications that support the biological activity of the product.

Chao et al (2009) Identification of N-(5-tert-butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea dihydrochloride (AC220), a uniquely potent, selective, and efficacious FMS-like ty J.Med.Chem. 52 7808 PMID: 19754199

Zarrinkar et al (2009) AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML). Blood. 114 2984 PMID: 19654408


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Keywords: Quizartinib, Quizartinib supplier, FLT3, inhibitors, inhibits, FMS-like, receptor, tyrosine, kinase-3, CD135, acute, myeloid, leukemia, AML, 6788, Tocris Bioscience

1 Citation for Quizartinib

Citations are publications that use Tocris products. Selected citations for Quizartinib include:

Thoas et al (2021) Combinatorial molecule screening identified a novel diterpene and the BET inhibitor CPI-203 as differentiation inducers of primary acute myeloid leukemia cells. Haematologica 106 2566-2577 PMID: 32855276


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