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Highly potent anaplastic lymphoma kinase (ALK) inhibitor (IC50 = 0.2 nM). Also displays potent inhibition of insulin receptor (IR), insulin-like growth factor receptor 1 (IGF1R), serine/threonine-protein kinase STK22D and FLT3 (IC50 values are 7, 8, 23 and 60 nM, respectively). Inhibits tumor growth in Karpas299 and H2228 rat xenograft models.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||2.79||5 with gentle warming|
|ethanol||2.79||5 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 558.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.05 mM||35.83 mL||179.17 mL||358.33 mL|
|0.25 mM||7.17 mL||35.83 mL||71.67 mL|
|0.5 mM||3.58 mL||17.92 mL||35.83 mL|
|2.5 mM||0.72 mL||3.58 mL||7.17 mL|
References are publications that support the biological activity of the product.
Marsilje et al (2013) Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl J.Med.Chem. 56 5675 PMID: 23742252
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Keywords: Ceritinib, Ceritinib supplier, LDK378, ALK, inhibitors, inhibits, highly, potent, Anaplastic, lymphoma, kinase, insulin, receptor, InsR, insulin-like, growth, factor, IGF1R, FLT3, STK22D, Insulin, and, Receptors, 6905, Tocris Bioscience
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