Dynole 34-2

Pricing Availability   Qty
Cat.No. 4222 - Dynole 34-2 | C25H36N4O | CAS No. 1128165-88-7
Description: Dynamin I inhibitor
Chemical Name: 2-Cyano-3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-N-octyl-2-propenamide
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Dynamin I inhibitor (IC50 = 1.3 μM). Inhibits receptor-mediated endocytosis (RME) (IC50 = 5.0 μM).

Compound Libraries

Dynole 34-2 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 408.58
Formula C25H36N4O
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1128165-88-7
PubChem ID 44157463
InChI Key MYIMRONQBLZJFI-DYTRJAOYSA-N
Smiles CN(C)CCCN2C1=CC=CC=C1C(/C=C(C(NCCCCCCCC)=O)\C#N)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.86 100
ethanol 20.43 50

Preparing Stock Solutions

The following data is based on the product molecular weight 408.58. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.45 mL 12.24 mL 24.48 mL
5 mM 0.49 mL 2.45 mL 4.9 mL
10 mM 0.24 mL 1.22 mL 2.45 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Hill et al (2009) Inhibition of dynamin mediated endocytosis by the dynoles - synthesis and functional activity of a family of indoles. J.Med.Chem. 52 3762 PMID: 19459681

Hill et al (2010) Iminochromene inhibitors of dynamins I and II GTPase activity and endocytosis. J.Med.Chem. 53 4094 PMID: 20426422


If you know of a relevant reference for Dynole 34-2, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Dynamin Inhibitors

Keywords: Dynole 34-2, Dynole 34-2 supplier, dynamin, I, inhibitors, inhibits, gtpases, rme, receptor-mediated, endocytosis, Dynamin, 4222, Tocris Bioscience

2 Citations for Dynole 34-2

Citations are publications that use Tocris products. Selected citations for Dynole 34-2 include:

Lasic (2017) Dynamin regulates the fusion pore of endo- and exocytotic vesicles as revealed by membrane capacitance measurements. Biochim Biophys Acta 1861 2293 PMID: 28669852

Han et al (2015) Combining valosin-containing protein (VCP) inhibition and suberanilohydroxamic acid (SAHA) treatment additively enhances the folding, trafficking, and function of epilepsy-associated γ-aminobutyric acid, type A (GABAA) receptors. Am J Physiol Cell Physiol 290 325 PMID: 25406314


Do you know of a great paper that uses Dynole 34-2 from Tocris? Please let us know.

Reviews for Dynole 34-2

There are currently no reviews for this product. Be the first to review Dynole 34-2 and earn rewards!

Have you used Dynole 34-2?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


New Product Guide

New Product Guide (Fall/Winter 2018/2019)

Our new product guide highlights over 190 new products added to the Tocris Bioscience range during the second half of 2018.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Chemogenetics
  • Epigenetics
  • Fluorescent Imaging
  • PROTACs
  • Signal Transduction
  • Stem Cells