Dynole 34-2

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Cat.No. 4222 - Dynole 34-2 | C25H36N4O | CAS No. 1128165-88-7
Description: Dynamin I inhibitor
Chemical Name: 2-Cyano-3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-N-octyl-2-propenamide
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Dynamin I inhibitor (IC50 = 1.3 μM). Inhibits receptor-mediated endocytosis (RME) (IC50 = 5.0 μM).

Compound Libraries

Dynole 34-2 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 408.58
Formula C25H36N4O
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1128165-88-7
PubChem ID 44157463
InChI Key MYIMRONQBLZJFI-DYTRJAOYSA-N
Smiles CN(C)CCCN2C1=CC=CC=C1C(/C=C(C(NCCCCCCCC)=O)\C#N)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.86 100
ethanol 20.43 50

Preparing Stock Solutions

The following data is based on the product molecular weight 408.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.45 mL 12.24 mL 24.48 mL
5 mM 0.49 mL 2.45 mL 4.9 mL
10 mM 0.24 mL 1.22 mL 2.45 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Hill et al (2009) Inhibition of dynamin mediated endocytosis by the dynoles - synthesis and functional activity of a family of indoles. J.Med.Chem. 52 3762 PMID: 19459681

Hill et al (2010) Iminochromene inhibitors of dynamins I and II GTPase activity and endocytosis. J.Med.Chem. 53 4094 PMID: 20426422


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Keywords: Dynole 34-2, supplier, dynamin, I, inhibitors, inhibits, gtpases, rme, receptor-mediated, endocytosis, GTPase, Tocris Bioscience

1 Citation for Dynole 34-2

Citations are publications that use Tocris products. Selected citations for Dynole 34-2 include:

Han et al (2015) Combining valosin-containing protein (VCP) inhibition and suberanilohydroxamic acid (SAHA) treatment additively enhances the folding, trafficking, and function of epilepsy-associated γ-aminobutyric acid, type A (GABAA) receptors. Am J Physiol Cell Physiol 290 325 PMID: 25406314


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Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

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  • Signal Transduction
  • Stem Cells

Pathways for Dynole 34-2

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