Hydroxy Dynasore

Pricing Availability   Qty
Description: Dynamin inhibitor; analog of dynasore (Cat. No. 2897)
Alternative Names: Dyngo 4a
Chemical Name: 3-Hydroxynaphthalene-2-carboxylic acid 2-[(2,4,5)-trihydroxyphenyl)methylene]hydrazide
Purity: ≥98% (HPLC)

Biological Activity for Hydroxy Dynasore

Hydroxy Dynasore is a dynamin inhibitor (IC50 values are 0.38 and 2.6 μM for dynamin 1 and 2 respectively). Inhibits dynamin-mediated endocytosis in multiple cell types and reduces synaptic vesicle endocytosis in vitro. Prevents botulinum A internalization in hippocampal neurons. Also protects against botulinum A-induced muscle paralysis in rats. Analog of Dynasore (Cat. No. 2897).

Technical Data for Hydroxy Dynasore

M. Wt 338.31
Formula C18H14N2O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1256493-34-1
PubChem ID 72193863
Smiles OC1=CC2=CC=CC=C2C=C1C(N/N=C/C3=C(O)C=C(O)C(O)=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Hydroxy Dynasore

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 32.23 100

Preparing Stock Solutions for Hydroxy Dynasore

The following data is based on the product molecular weight 338.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.96 mL 14.78 mL 29.56 mL
5 mM 0.59 mL 2.96 mL 5.91 mL
10 mM 0.3 mL 1.48 mL 2.96 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for Hydroxy Dynasore

References for Hydroxy Dynasore

References are publications that support the biological activity of the product.

Harper et al (2011) Dynamin inhibition blocks botulinum neurotoxin type A endocytosis in neurons and delays botulism. J.Biol.Chem. 286 35966 PMID: 21832053

McCluskey et al (2013) Building a better dynasore: the dyngo compounds potently inhibit dynamin and endocytosis. Traffic 14 1272 PMID: 24025110

If you know of a relevant reference for Hydroxy Dynasore, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Dynamin Inhibitors

Keywords: Hydroxy Dynasore, Hydroxy Dynasore supplier, dynamin, gtpases, dynamin1, dynamin2, endocytosis, botulinum, Dyngo, 4a, Dynamin, 5364, Tocris Bioscience

Citations for Hydroxy Dynasore

Citations are publications that use Tocris products.

Currently there are no citations for Hydroxy Dynasore. Do you know of a great paper that uses Hydroxy Dynasore from Tocris? Please let us know.

Reviews for Hydroxy Dynasore

There are currently no reviews for this product. Be the first to review Hydroxy Dynasore and earn rewards!

Have you used Hydroxy Dynasore?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review