Hydroxy Dynasore

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Cat.No. 5364 - Hydroxy Dynasore | C18H14N2O5 | CAS No. 1256493-34-1
Description: Dynamin inhibitor; analog of dynasore (Cat. No. 2897)
Chemical Name: 3-Hydroxynaphthalene-2-carboxylic acid 2-[(2,4,5)-trihydroxyphenyl)methylene]hydrazide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Dynamin inhibitor (IC50 values are 0.38 and 2.6 μM for dynamin 1 and 2 respectively). Inhibits dynamin-mediated endocytosis in multiple cell types and reduces synaptic vesicle endocytosis in vitro. Prevents botulinum A internalization in hippocampal neurons. Also protects against botulinum A-induced muscle paralysis in rats. Analog of Dynasore (Cat. No. 2897).

Technical Data

M. Wt 338.31
Formula C18H14N2O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1256493-34-1
PubChem ID 72193863
InChI Key ATUDAZGVGGVSOP-XFXZXTDPSA-N
Smiles OC1=CC2=CC=CC=C2C=C1C(N/N=C/C3=C(O)C=C(O)C(O)=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.23 100

Preparing Stock Solutions

The following data is based on the product molecular weight 338.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.96 mL 14.78 mL 29.56 mL
5 mM 0.59 mL 2.96 mL 5.91 mL
10 mM 0.3 mL 1.48 mL 2.96 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Harper et al (2011) Dynamin inhibition blocks botulinum neurotoxin type A endocytosis in neurons and delays botulism. J.Biol.Chem. 286 35966 PMID: 21832053

McCluskey et al (2013) Building a better dynasore: the dyngo compounds potently inhibit dynamin and endocytosis. Traffic 14 1272 PMID: 24025110


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Keywords: Hydroxy Dynasore, supplier, dynamin, gtpases, dynamin1, dynamin2, endocytosis, botulinum, GTPase, GTPase, Tocris Bioscience

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