AZD 7648

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Description: Potent and selective DNA-PK inhibitor; enhances CRISPR-mediated HDR efficiency
Chemical Name: 7,9-Dihydro-7-methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-8H-purin-8-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity for AZD 7648

AZD 7648 is a potent (IC50 = 0.6 nM in an enzyme assay) and selective DNA-PK inhibitor. It is selective for DNA-PK over a range of kinases including PI3Kα, PI3Kδ, PI3Kγ, ATM, ATR and mTOR. In combination with radiotherapy, it leads to tumor regression in fully immuno-competent mice models. It also enhances the activity of PARP inhibitor Olaparib (Cat. No. 7579). AZD 7648 is orally bioavailable. AZD 7648 also enhances CRISPR-mediated HDR efficiency.

Technical Data for AZD 7648

M. Wt 380.41
Formula C18H20N8O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2230820-11-6
PubChem ID 135151360
InChI Key XISVSTPEXYIKJL-UHFFFAOYSA-N
Smiles O=C1N(C)C2=CN=C(NC3=CN4N=CN=C4C=C3C)N=C2N1C5CCOCC5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AZD 7648

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.61 20

Preparing Stock Solutions for AZD 7648

The following data is based on the product molecular weight 380.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 13.14 mL 65.72 mL 131.44 mL
1 mM 2.63 mL 13.14 mL 26.29 mL
2 mM 1.31 mL 6.57 mL 13.14 mL
10 mM 0.26 mL 1.31 mL 2.63 mL

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Citations for AZD 7648

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Literature in this Area

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