CCK2 Receptors

The cholecystokinin2 receptor (CCK2 receptor, CCK-B receptor) is a member of the cholecystokinin receptor group of G-protein-coupled receptors that also includes CCK1. They are located primarily in the brain, spinal cord and stomach and influence neurotransmission.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
3006 Gastrin I (human)
Selective CCK2 agonist

Antagonists

Cat No Product Name / Activity
2607 CI 988
Potent and selective CCK2 antagonist
2767 L-365,260
Selective CCK2 antagonist
1018 LY 225910
Potent CCK2 antagonist
1524 LY 288513
Selective CCK2 antagonist
2608 PD 135158
Potent and selective CCK2 antagonist
1408 YM 022
Highly potent, selective non-peptide CCK2 antagonist

Related Targets

    The cholecystokinin2 receptor (CCK2 receptor, CCK-B receptor) is a member of the cholecystokinin receptor group of G-protein-coupled receptors that also includes CCK1. They are located primarily in the brain, spinal cord and stomach where they play a role in anxiety, nociception, neuroleptic activity, gastric acid release, gastric mucosal cell growth and histamine release. The human CCK2 receptor gene has been localized to chromosome 11 (11p15.4).

    External sources of pharmacological information for CCK2 Receptors :

    Literature for CCK2 Receptors

    GPCR

    GPCR Product Listing

    A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

    • Rhodopsin-like Receptors
    • Secretin-like Receptors
    • Glutamate Receptors
    • Frizzled Receptors
    • GPCR Signaling
    Peptide Hormone Receptors

    Peptide Hormone Receptors Product Listing

    A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

    • Anterior Pituitary Regulation
    • Blood Pressure Regulation
    • Feeding and Appetite Regulation
    • Glucose Regulation
    • Peptide Hormone Processing
    Peptides Involved in Appetite Modulation

    Peptides Involved in Appetite Modulation Scientific Review

    Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

    CCK2 Receptor Gene Data

    Species Gene Symbol Gene Accession No. Protein Accession No.
    Human CCKBR NM_176875 P32239
    Mouse Cckbr NM_007627 P56481
    Rat Cckbr NM_013165 P30553